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Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma

Gastric cancer is a common malignancy and remains one of the leading causes of cancer-related deaths, though its incidence is in decline in most developed countries. One of the major challenges of treating gastric cancer is tumor heterogeneity, which portends a high degree of prognostic variance and...

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Autores principales: Luo, Wenyi, Nagaria, Teddy S., Sun, Hongxia, Ma, Junsheng, Lombardo, Jamie L., Bassett, Roland, Cao, Austin C., Tan, Dongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863590/
https://www.ncbi.nlm.nih.gov/pubmed/35221802
http://dx.doi.org/10.3389/pore.2022.1610293
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author Luo, Wenyi
Nagaria, Teddy S.
Sun, Hongxia
Ma, Junsheng
Lombardo, Jamie L.
Bassett, Roland
Cao, Austin C.
Tan, Dongfeng
author_facet Luo, Wenyi
Nagaria, Teddy S.
Sun, Hongxia
Ma, Junsheng
Lombardo, Jamie L.
Bassett, Roland
Cao, Austin C.
Tan, Dongfeng
author_sort Luo, Wenyi
collection PubMed
description Gastric cancer is a common malignancy and remains one of the leading causes of cancer-related deaths, though its incidence is in decline in most developed countries. One of the major challenges of treating gastric cancer is tumor heterogeneity, which portends a high degree of prognostic variance and the necessity for different treatment modalities. Tumor heterogeneity is at least in part due to divergent differentiation of tumor cells to clones harboring different molecular alterations. Here we studied the expression of emerging prognostic markers SOX9, MCL-1, and SPOCK1 (Testican-1) in a cohort of gastric cancer by immunohistochemistry and investigated how individual biomarkers and their combinations predict disease prognosis. We found frequent expression of SPOCK1 (in both nuclei and cytoplasm), MCL-1 and SOX9 in gastric cancer. In univariate analysis, nuclear SPOCK1 expression and pathologic TNM stage were negative prognostic markers in this cohort. In multivariate analysis, SOX9 expression stood out as a predictor of poor prognosis. Further subgroup analysis suggested prognostic value of SOX9 expression in poorly differentiated gastric adenocarcinoma. MCL-1 showed no prognostic role in this cohort.
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spelling pubmed-88635902022-02-24 Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma Luo, Wenyi Nagaria, Teddy S. Sun, Hongxia Ma, Junsheng Lombardo, Jamie L. Bassett, Roland Cao, Austin C. Tan, Dongfeng Pathol Oncol Res Pathology and Oncology Archive Gastric cancer is a common malignancy and remains one of the leading causes of cancer-related deaths, though its incidence is in decline in most developed countries. One of the major challenges of treating gastric cancer is tumor heterogeneity, which portends a high degree of prognostic variance and the necessity for different treatment modalities. Tumor heterogeneity is at least in part due to divergent differentiation of tumor cells to clones harboring different molecular alterations. Here we studied the expression of emerging prognostic markers SOX9, MCL-1, and SPOCK1 (Testican-1) in a cohort of gastric cancer by immunohistochemistry and investigated how individual biomarkers and their combinations predict disease prognosis. We found frequent expression of SPOCK1 (in both nuclei and cytoplasm), MCL-1 and SOX9 in gastric cancer. In univariate analysis, nuclear SPOCK1 expression and pathologic TNM stage were negative prognostic markers in this cohort. In multivariate analysis, SOX9 expression stood out as a predictor of poor prognosis. Further subgroup analysis suggested prognostic value of SOX9 expression in poorly differentiated gastric adenocarcinoma. MCL-1 showed no prognostic role in this cohort. Frontiers Media S.A. 2022-02-09 /pmc/articles/PMC8863590/ /pubmed/35221802 http://dx.doi.org/10.3389/pore.2022.1610293 Text en Copyright © 2022 Luo, Nagaria, Sun, Ma, Lombardo, Bassett, Cao and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pathology and Oncology Archive
Luo, Wenyi
Nagaria, Teddy S.
Sun, Hongxia
Ma, Junsheng
Lombardo, Jamie L.
Bassett, Roland
Cao, Austin C.
Tan, Dongfeng
Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
title Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
title_full Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
title_fullStr Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
title_full_unstemmed Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
title_short Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
title_sort expression and potential prognostic value of sox9, mcl-1 and spock1 in gastric adenocarcinoma
topic Pathology and Oncology Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863590/
https://www.ncbi.nlm.nih.gov/pubmed/35221802
http://dx.doi.org/10.3389/pore.2022.1610293
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