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Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss

Our objective was to study the characteristics of patients with subjective tinnitus and normal hearing and to investigate whether the features correlated to different shapes on audiograms. In this retrospective study, 313 patients with subjective tinnitus and clinically normal hearing were enrolled...

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Autores principales: Tang, Dongmei, Lu, Xiaoling, Huang, Ruonan, Yu, Huiqian, Li, Wenyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863606/
https://www.ncbi.nlm.nih.gov/pubmed/35221921
http://dx.doi.org/10.3389/fncel.2022.804745
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author Tang, Dongmei
Lu, Xiaoling
Huang, Ruonan
Yu, Huiqian
Li, Wenyan
author_facet Tang, Dongmei
Lu, Xiaoling
Huang, Ruonan
Yu, Huiqian
Li, Wenyan
author_sort Tang, Dongmei
collection PubMed
description Our objective was to study the characteristics of patients with subjective tinnitus and normal hearing and to investigate whether the features correlated to different shapes on audiograms. In this retrospective study, 313 patients with subjective tinnitus and clinically normal hearing were enrolled from the tinnitus outpatient department of the Eye and ENT Hospital of Fudan University. The following phenotypic variables were collected: age, dominant tinnitus pitch (TP), tinnitus loudness, tinnitus duration, tinnitus severity, sex, education, hearing thresholds, tinnitus position, and tinnitus condition. The dominant TPs of patients with normal hearing were mostly high-pitched, with a mean of 4866.8 ± 2579.6 Hz; thus, we speculated that the condition is related to high-frequency hearing threshold elevations. We further divided the patients into four subgroups based on the matched TP: (i) TP ≤ 500 Hz (n = 34), (ii) 500 Hz < TP ≤ 3,000 Hz (n = 15), (iii) 3,000 Hz < TP ≤ 8,000 Hz (n = 259), and (iv) TP > 8,000 Hz (n = 5). We studied the phenotypic profiling of different audiograms and found that the group with TP of ≤500 Hz had an average “inverted-U” shaped audiogram, and the group with TP between 500 and 3,000 Hz had a slowly ascending slope audiogram below 2,000 Hz, followed by a drastically descending slope audiogram ranging from 2,000 to 8,000 Hz; further, the high-frequency (3,000–8,000 Hz) and ultra-high-frequency (>8,000 Hz) groups had flat curves below 2,000 Hz and steeper slope audiograms over 2,000 Hz. Our findings confirmed a consistency ratio between the distributions of dominant TPs and the frequencies of maximum hearing thresholds in both ears. The dominant TP was positively correlated with the maximum hearing threshold elevation frequency (left ear: r = 0.277, p < 0.05; right ear: r = 0.367, p < 0.001). Hearing threshold elevations, especially in high frequency, might explain the appearance of dominant high-frequency TP in patients without clinically defined hearing loss. This is consistent with the causal role of high-frequency coding in the generation of tinnitus.
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spelling pubmed-88636062022-02-24 Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss Tang, Dongmei Lu, Xiaoling Huang, Ruonan Yu, Huiqian Li, Wenyan Front Cell Neurosci Neuroscience Our objective was to study the characteristics of patients with subjective tinnitus and normal hearing and to investigate whether the features correlated to different shapes on audiograms. In this retrospective study, 313 patients with subjective tinnitus and clinically normal hearing were enrolled from the tinnitus outpatient department of the Eye and ENT Hospital of Fudan University. The following phenotypic variables were collected: age, dominant tinnitus pitch (TP), tinnitus loudness, tinnitus duration, tinnitus severity, sex, education, hearing thresholds, tinnitus position, and tinnitus condition. The dominant TPs of patients with normal hearing were mostly high-pitched, with a mean of 4866.8 ± 2579.6 Hz; thus, we speculated that the condition is related to high-frequency hearing threshold elevations. We further divided the patients into four subgroups based on the matched TP: (i) TP ≤ 500 Hz (n = 34), (ii) 500 Hz < TP ≤ 3,000 Hz (n = 15), (iii) 3,000 Hz < TP ≤ 8,000 Hz (n = 259), and (iv) TP > 8,000 Hz (n = 5). We studied the phenotypic profiling of different audiograms and found that the group with TP of ≤500 Hz had an average “inverted-U” shaped audiogram, and the group with TP between 500 and 3,000 Hz had a slowly ascending slope audiogram below 2,000 Hz, followed by a drastically descending slope audiogram ranging from 2,000 to 8,000 Hz; further, the high-frequency (3,000–8,000 Hz) and ultra-high-frequency (>8,000 Hz) groups had flat curves below 2,000 Hz and steeper slope audiograms over 2,000 Hz. Our findings confirmed a consistency ratio between the distributions of dominant TPs and the frequencies of maximum hearing thresholds in both ears. The dominant TP was positively correlated with the maximum hearing threshold elevation frequency (left ear: r = 0.277, p < 0.05; right ear: r = 0.367, p < 0.001). Hearing threshold elevations, especially in high frequency, might explain the appearance of dominant high-frequency TP in patients without clinically defined hearing loss. This is consistent with the causal role of high-frequency coding in the generation of tinnitus. Frontiers Media S.A. 2022-02-09 /pmc/articles/PMC8863606/ /pubmed/35221921 http://dx.doi.org/10.3389/fncel.2022.804745 Text en Copyright © 2022 Tang, Lu, Huang, Yu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tang, Dongmei
Lu, Xiaoling
Huang, Ruonan
Yu, Huiqian
Li, Wenyan
Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss
title Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss
title_full Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss
title_fullStr Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss
title_full_unstemmed Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss
title_short Phenotypic Profiling of People With Subjective Tinnitus and Without a Clinical Hearing Loss
title_sort phenotypic profiling of people with subjective tinnitus and without a clinical hearing loss
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863606/
https://www.ncbi.nlm.nih.gov/pubmed/35221921
http://dx.doi.org/10.3389/fncel.2022.804745
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