Cargando…

Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC

Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) is an important pair of immune checkpoints (IC), which play an essential role in the immune escaping process of tumors. Anti-PD-1/PD-L1 immunotherapy can block the suppression effect of the immune system produced by tumor cells through...

Descripción completa

Detalles Bibliográficos
Autores principales: Bie, Fenglong, Tian, He, Sun, Nan, Zang, Ruochuan, Zhang, Moyan, Song, Peng, Liu, Lei, Peng, Yue, Bai, Guangyu, Zhou, Bolun, Gao, Shugeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863729/
https://www.ncbi.nlm.nih.gov/pubmed/35223466
http://dx.doi.org/10.3389/fonc.2022.769124
_version_ 1784655293849796608
author Bie, Fenglong
Tian, He
Sun, Nan
Zang, Ruochuan
Zhang, Moyan
Song, Peng
Liu, Lei
Peng, Yue
Bai, Guangyu
Zhou, Bolun
Gao, Shugeng
author_facet Bie, Fenglong
Tian, He
Sun, Nan
Zang, Ruochuan
Zhang, Moyan
Song, Peng
Liu, Lei
Peng, Yue
Bai, Guangyu
Zhou, Bolun
Gao, Shugeng
author_sort Bie, Fenglong
collection PubMed
description Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) is an important pair of immune checkpoints (IC), which play an essential role in the immune escaping process of tumors. Anti-PD-1/PD-L1 immunotherapy can block the suppression effect of the immune system produced by tumor cells through the PD-1/PD-L1 axis and restore the pernicious effect of the immune system on tumor cells. The specific mechanism of anti-PD-1/PD-L1 immunotherapy is closely related to PI3K (phosphatidylinositol 3-kinase)/AKT (AKT serine/threonine kinase 1), JNK (c-Jun N-terminal kinase), NF-kB (nuclear factor-kappa B subunit 1), and other complex signaling pathways. Patients receiving anti-PD-1/PD-L1 immunotherapy are prone to drug resistance. The mechanisms of drug resistance mainly include weakening recognition of tumor antigens by immune cells, inhibiting activation of immune cells, and promoting the production of suppressive immune cells and molecules. Anti-PD-1/PD-L1 immunotherapy plays a vital role in non-small cell lung cancer (NSCLC). It is essential to find better efficacy prediction-related biomarkers and screen patients suitable for immunotherapy. At present, common biomarkers related to predicting immune efficacy mainly include PD-L1 expression level in tumors, tumor mutation burden (TMB), microsatellite instability (MSI)/mismatch repair (MMR), mutations of driver gene, etc. However, the screening efficacy of each indicator is not ideal, and the combined application of multiple indicators is currently used. This article comprehensively reviews anti-PD-1/PD-L1 immunotherapy-related mechanisms, drug resistance-related mechanisms, and therapeutic efficacy-related predictive biomarkers.
format Online
Article
Text
id pubmed-8863729
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88637292022-02-24 Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC Bie, Fenglong Tian, He Sun, Nan Zang, Ruochuan Zhang, Moyan Song, Peng Liu, Lei Peng, Yue Bai, Guangyu Zhou, Bolun Gao, Shugeng Front Oncol Oncology Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) is an important pair of immune checkpoints (IC), which play an essential role in the immune escaping process of tumors. Anti-PD-1/PD-L1 immunotherapy can block the suppression effect of the immune system produced by tumor cells through the PD-1/PD-L1 axis and restore the pernicious effect of the immune system on tumor cells. The specific mechanism of anti-PD-1/PD-L1 immunotherapy is closely related to PI3K (phosphatidylinositol 3-kinase)/AKT (AKT serine/threonine kinase 1), JNK (c-Jun N-terminal kinase), NF-kB (nuclear factor-kappa B subunit 1), and other complex signaling pathways. Patients receiving anti-PD-1/PD-L1 immunotherapy are prone to drug resistance. The mechanisms of drug resistance mainly include weakening recognition of tumor antigens by immune cells, inhibiting activation of immune cells, and promoting the production of suppressive immune cells and molecules. Anti-PD-1/PD-L1 immunotherapy plays a vital role in non-small cell lung cancer (NSCLC). It is essential to find better efficacy prediction-related biomarkers and screen patients suitable for immunotherapy. At present, common biomarkers related to predicting immune efficacy mainly include PD-L1 expression level in tumors, tumor mutation burden (TMB), microsatellite instability (MSI)/mismatch repair (MMR), mutations of driver gene, etc. However, the screening efficacy of each indicator is not ideal, and the combined application of multiple indicators is currently used. This article comprehensively reviews anti-PD-1/PD-L1 immunotherapy-related mechanisms, drug resistance-related mechanisms, and therapeutic efficacy-related predictive biomarkers. Frontiers Media S.A. 2022-02-09 /pmc/articles/PMC8863729/ /pubmed/35223466 http://dx.doi.org/10.3389/fonc.2022.769124 Text en Copyright © 2022 Bie, Tian, Sun, Zang, Zhang, Song, Liu, Peng, Bai, Zhou and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bie, Fenglong
Tian, He
Sun, Nan
Zang, Ruochuan
Zhang, Moyan
Song, Peng
Liu, Lei
Peng, Yue
Bai, Guangyu
Zhou, Bolun
Gao, Shugeng
Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC
title Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC
title_full Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC
title_fullStr Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC
title_full_unstemmed Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC
title_short Research Progress of Anti-PD-1/PD-L1 Immunotherapy Related Mechanisms and Predictive Biomarkers in NSCLC
title_sort research progress of anti-pd-1/pd-l1 immunotherapy related mechanisms and predictive biomarkers in nsclc
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863729/
https://www.ncbi.nlm.nih.gov/pubmed/35223466
http://dx.doi.org/10.3389/fonc.2022.769124
work_keys_str_mv AT biefenglong researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT tianhe researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT sunnan researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT zangruochuan researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT zhangmoyan researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT songpeng researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT liulei researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT pengyue researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT baiguangyu researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT zhoubolun researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc
AT gaoshugeng researchprogressofantipd1pdl1immunotherapyrelatedmechanismsandpredictivebiomarkersinnsclc