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Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update

Sleep disorders (SDs) represent an important issue in patients with craniopharyngioma (CP). Nearly 70% of these patients complain of sleep-wake cycle alterations and/or excessive diurnal somnolence due to sleep-related breathing disorders, such as obstructive sleep apnea (OSA) and/or central hyperso...

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Autores principales: Romigi, Andrea, Feola, Tiziana, Cappellano, Simone, De Angelis, Michelangelo, Pio, Giacomo, Caccamo, Marco, Testa, Federica, Vitrani, Giuseppe, Centonze, Diego, Colonnese, Claudio, Esposito, Vincenzo, Jaffrain-Rea, Marie-Lise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863754/
https://www.ncbi.nlm.nih.gov/pubmed/35222233
http://dx.doi.org/10.3389/fneur.2021.817257
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author Romigi, Andrea
Feola, Tiziana
Cappellano, Simone
De Angelis, Michelangelo
Pio, Giacomo
Caccamo, Marco
Testa, Federica
Vitrani, Giuseppe
Centonze, Diego
Colonnese, Claudio
Esposito, Vincenzo
Jaffrain-Rea, Marie-Lise
author_facet Romigi, Andrea
Feola, Tiziana
Cappellano, Simone
De Angelis, Michelangelo
Pio, Giacomo
Caccamo, Marco
Testa, Federica
Vitrani, Giuseppe
Centonze, Diego
Colonnese, Claudio
Esposito, Vincenzo
Jaffrain-Rea, Marie-Lise
author_sort Romigi, Andrea
collection PubMed
description Sleep disorders (SDs) represent an important issue in patients with craniopharyngioma (CP). Nearly 70% of these patients complain of sleep-wake cycle alterations and/or excessive diurnal somnolence due to sleep-related breathing disorders, such as obstructive sleep apnea (OSA) and/or central hypersomnia, including secondary narcolepsy. SDs may severely reduce quality of life, increase disease-related cardiorespiratory and cardiovascular morbidity, and finally play a major role in increased long-term mortality reported on patients with CP. A major risk factor for SDs is represented by the hypothalamic syndrome, which may develop because of direct hypothalamic damage by the tumor itself and/or complications of the treatments, neurosurgery and/or radiotherapy, and typically includes permanent neuroendocrine dysfunctions, morbid obesity, and secondary metabolic disorders. Despite increasing attention to SDs in the general population, and in particular to OSA as a risk factor for cardio-metabolic diseases and excessive daytime somnolence, sleep evaluation is still not routinely proposed to patients with CP. Hence, SDs are often underdiagnosed and undertreated. The aim of this paper is to update current knowledge of the pathogenesis and prevalence of SDs in patients with CP and propose practical algorithms for their evaluation and management in clinical practice. Particular attention is paid to screening and diagnostic tools for appropriate characterization of SDs, identification of risk factors, and potential role of hypothalamic sparing surgery in the prevention of morbid obesity and SDs. Available tools in sleep medicine, including lifestyle interventions, drugs, and respiratory devices, are discussed, as well as the importance of optimal hormone replacement and metabolic interventions. Current limits in the diagnosis and treatment of SDs in patients with CP and possible future avenues for research agenda are also considered.
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spelling pubmed-88637542022-02-24 Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update Romigi, Andrea Feola, Tiziana Cappellano, Simone De Angelis, Michelangelo Pio, Giacomo Caccamo, Marco Testa, Federica Vitrani, Giuseppe Centonze, Diego Colonnese, Claudio Esposito, Vincenzo Jaffrain-Rea, Marie-Lise Front Neurol Neurology Sleep disorders (SDs) represent an important issue in patients with craniopharyngioma (CP). Nearly 70% of these patients complain of sleep-wake cycle alterations and/or excessive diurnal somnolence due to sleep-related breathing disorders, such as obstructive sleep apnea (OSA) and/or central hypersomnia, including secondary narcolepsy. SDs may severely reduce quality of life, increase disease-related cardiorespiratory and cardiovascular morbidity, and finally play a major role in increased long-term mortality reported on patients with CP. A major risk factor for SDs is represented by the hypothalamic syndrome, which may develop because of direct hypothalamic damage by the tumor itself and/or complications of the treatments, neurosurgery and/or radiotherapy, and typically includes permanent neuroendocrine dysfunctions, morbid obesity, and secondary metabolic disorders. Despite increasing attention to SDs in the general population, and in particular to OSA as a risk factor for cardio-metabolic diseases and excessive daytime somnolence, sleep evaluation is still not routinely proposed to patients with CP. Hence, SDs are often underdiagnosed and undertreated. The aim of this paper is to update current knowledge of the pathogenesis and prevalence of SDs in patients with CP and propose practical algorithms for their evaluation and management in clinical practice. Particular attention is paid to screening and diagnostic tools for appropriate characterization of SDs, identification of risk factors, and potential role of hypothalamic sparing surgery in the prevention of morbid obesity and SDs. Available tools in sleep medicine, including lifestyle interventions, drugs, and respiratory devices, are discussed, as well as the importance of optimal hormone replacement and metabolic interventions. Current limits in the diagnosis and treatment of SDs in patients with CP and possible future avenues for research agenda are also considered. Frontiers Media S.A. 2022-02-09 /pmc/articles/PMC8863754/ /pubmed/35222233 http://dx.doi.org/10.3389/fneur.2021.817257 Text en Copyright © 2022 Romigi, Feola, Cappellano, De Angelis, Pio, Caccamo, Testa, Vitrani, Centonze, Colonnese, Esposito and Jaffrain-Rea. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Romigi, Andrea
Feola, Tiziana
Cappellano, Simone
De Angelis, Michelangelo
Pio, Giacomo
Caccamo, Marco
Testa, Federica
Vitrani, Giuseppe
Centonze, Diego
Colonnese, Claudio
Esposito, Vincenzo
Jaffrain-Rea, Marie-Lise
Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update
title Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update
title_full Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update
title_fullStr Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update
title_full_unstemmed Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update
title_short Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update
title_sort sleep disorders in patients with craniopharyngioma: a physiopathological and practical update
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863754/
https://www.ncbi.nlm.nih.gov/pubmed/35222233
http://dx.doi.org/10.3389/fneur.2021.817257
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