Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy

Although patients with nonalcoholic fatty liver disease have been reported to have cardiac dysfunction, and appropriate model has not been reported. We established a novel mouse model of diet-induced steatohepatitis-related cardiomyopathy and evaluated the effect of pemafibrate. C57Bl/6 male mice we...

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Detalles Bibliográficos
Autores principales: Kanno, Kotaro, Koseki, Masahiro, Chang, Jiuyang, Saga, Ayami, Inui, Hiroyasu, Okada, Takeshi, Tanaka, Katsunao, Asaji, Masumi, Zhu, Yinghong, Ide, Seiko, Saito, Shigeyoshi, Higo, Tomoaki, Okuzaki, Daisuke, Ohama, Tohru, Nishida, Makoto, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Yamashita, Shizuya, Sakata, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863801/
https://www.ncbi.nlm.nih.gov/pubmed/35194060
http://dx.doi.org/10.1038/s41598-022-06542-8

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