Tumor cell enrichment by tissue suspension enables detection of mutations with low variant allele frequency and estimation of germline mutations

Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing cannot be performed in cancers harboring diffuse tumor cells because of low tumor content. We performed tumor cell enrichment using tissue suspens...

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Detalles Bibliográficos
Autores principales: Hatakeyama, Keiichi, Muramatsu, Koji, Nagashima, Takeshi, Kawanishi, Yuichi, Fukumura, Ryutaro, Ohshima, Keiichi, Shimoda, Yuji, Kenmotsu, Hirotsugu, Mochizuki, Tohru, Urakami, Kenichi, Akiyama, Yasuto, Sugino, Takashi, Yamaguchi, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863826/
https://www.ncbi.nlm.nih.gov/pubmed/35194076
http://dx.doi.org/10.1038/s41598-022-06885-2

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