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Cytokine profile in drug-naïve panic disorder patients

Although accumulating evidence suggests that inflammatory processes play a role in the pathophysiology of mental disorders, few studies have investigated this matter in panic disorder (PD). Furthermore, no studies to date have evaluated cytokine levels in drug-naïve patients with PD. Therefore, litt...

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Autores principales: Quagliato, Laiana A., Nardi, Antonio E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863842/
https://www.ncbi.nlm.nih.gov/pubmed/35194013
http://dx.doi.org/10.1038/s41398-022-01835-y
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author Quagliato, Laiana A.
Nardi, Antonio E.
author_facet Quagliato, Laiana A.
Nardi, Antonio E.
author_sort Quagliato, Laiana A.
collection PubMed
description Although accumulating evidence suggests that inflammatory processes play a role in the pathophysiology of mental disorders, few studies have investigated this matter in panic disorder (PD). Furthermore, no studies to date have evaluated cytokine levels in drug-naïve patients with PD. Therefore, little is known about the presence of inflammation at the onset of this disorder. The aim of the present study was to determine the levels of the proinflammatory interleukins IL-1B and IL-2R and the anti-inflammatory cytokine IL-10 in drug-naïve PD patients. Analysis of serum chemokine levels revealed increased proinflammatory activity in the early phase of PD through increased IL-2R and IL-1B levels and a decrease in IL-10 levels in drug-naïve PD patients compared to matched healthy controls. Neurotransmitters and neurocircuits that are targets of inflammatory responses are discussed, followed by an examination of brain–immune interactions as risk factors for PD. This study is the first to identify a proinflammatory cytokine response in drug-naïve PD subjects. These findings indicate that treatments targeting proinflammatory markers may ameliorate anxiety symptoms in PD patients.
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spelling pubmed-88638422022-03-17 Cytokine profile in drug-naïve panic disorder patients Quagliato, Laiana A. Nardi, Antonio E. Transl Psychiatry Article Although accumulating evidence suggests that inflammatory processes play a role in the pathophysiology of mental disorders, few studies have investigated this matter in panic disorder (PD). Furthermore, no studies to date have evaluated cytokine levels in drug-naïve patients with PD. Therefore, little is known about the presence of inflammation at the onset of this disorder. The aim of the present study was to determine the levels of the proinflammatory interleukins IL-1B and IL-2R and the anti-inflammatory cytokine IL-10 in drug-naïve PD patients. Analysis of serum chemokine levels revealed increased proinflammatory activity in the early phase of PD through increased IL-2R and IL-1B levels and a decrease in IL-10 levels in drug-naïve PD patients compared to matched healthy controls. Neurotransmitters and neurocircuits that are targets of inflammatory responses are discussed, followed by an examination of brain–immune interactions as risk factors for PD. This study is the first to identify a proinflammatory cytokine response in drug-naïve PD subjects. These findings indicate that treatments targeting proinflammatory markers may ameliorate anxiety symptoms in PD patients. Nature Publishing Group UK 2022-02-22 /pmc/articles/PMC8863842/ /pubmed/35194013 http://dx.doi.org/10.1038/s41398-022-01835-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Quagliato, Laiana A.
Nardi, Antonio E.
Cytokine profile in drug-naïve panic disorder patients
title Cytokine profile in drug-naïve panic disorder patients
title_full Cytokine profile in drug-naïve panic disorder patients
title_fullStr Cytokine profile in drug-naïve panic disorder patients
title_full_unstemmed Cytokine profile in drug-naïve panic disorder patients
title_short Cytokine profile in drug-naïve panic disorder patients
title_sort cytokine profile in drug-naïve panic disorder patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863842/
https://www.ncbi.nlm.nih.gov/pubmed/35194013
http://dx.doi.org/10.1038/s41398-022-01835-y
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