Cargando…

A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19

Studies on the effects of school openings or closures during the Covid-19 pandemic seem to reach contrasting conclusions even in similar contexts. We aim at clarifying this controversy. A mathematical analysis of compartmental models with subpopulations has been conducted, starting from the SIR mode...

Descripción completa

Detalles Bibliográficos
Autores principales: Gandolfi, Alberto, Aspri, Andrea, Beretta, Elena, Jamshad, Khola, Jiang, Muyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863853/
https://www.ncbi.nlm.nih.gov/pubmed/35194065
http://dx.doi.org/10.1038/s41598-022-06540-w
_version_ 1784655323487797248
author Gandolfi, Alberto
Aspri, Andrea
Beretta, Elena
Jamshad, Khola
Jiang, Muyan
author_facet Gandolfi, Alberto
Aspri, Andrea
Beretta, Elena
Jamshad, Khola
Jiang, Muyan
author_sort Gandolfi, Alberto
collection PubMed
description Studies on the effects of school openings or closures during the Covid-19 pandemic seem to reach contrasting conclusions even in similar contexts. We aim at clarifying this controversy. A mathematical analysis of compartmental models with subpopulations has been conducted, starting from the SIR model, and progressively adding features modeling outbreaks or upsurge of variants, lockdowns, and vaccinations. We find that in all cases, the in-school transmission rates only affect the overall course of the pandemic above a certain context dependent threshold. We provide rigorous proofs and computations of the thresdhold through linearization. We then confirm our theoretical findings through simulations and the review of data-driven studies that exhibit an often unnoticed phase transition. Specific implications are: awareness about the threshold could inform choice of data collection, analysis and release, such as in-school transmission rates, and clarify the reason for divergent conclusions in similar studies; schools may remain open at any stage of the Covid-19 pandemic, including variants upsurge, given suitable containment rules; these rules would be extremely strict and hardly sustainable if only adults are vaccinated, making a compelling argument for vaccinating children whenever possible.
format Online
Article
Text
id pubmed-8863853
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-88638532022-02-23 A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19 Gandolfi, Alberto Aspri, Andrea Beretta, Elena Jamshad, Khola Jiang, Muyan Sci Rep Article Studies on the effects of school openings or closures during the Covid-19 pandemic seem to reach contrasting conclusions even in similar contexts. We aim at clarifying this controversy. A mathematical analysis of compartmental models with subpopulations has been conducted, starting from the SIR model, and progressively adding features modeling outbreaks or upsurge of variants, lockdowns, and vaccinations. We find that in all cases, the in-school transmission rates only affect the overall course of the pandemic above a certain context dependent threshold. We provide rigorous proofs and computations of the thresdhold through linearization. We then confirm our theoretical findings through simulations and the review of data-driven studies that exhibit an often unnoticed phase transition. Specific implications are: awareness about the threshold could inform choice of data collection, analysis and release, such as in-school transmission rates, and clarify the reason for divergent conclusions in similar studies; schools may remain open at any stage of the Covid-19 pandemic, including variants upsurge, given suitable containment rules; these rules would be extremely strict and hardly sustainable if only adults are vaccinated, making a compelling argument for vaccinating children whenever possible. Nature Publishing Group UK 2022-02-22 /pmc/articles/PMC8863853/ /pubmed/35194065 http://dx.doi.org/10.1038/s41598-022-06540-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gandolfi, Alberto
Aspri, Andrea
Beretta, Elena
Jamshad, Khola
Jiang, Muyan
A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19
title A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19
title_full A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19
title_fullStr A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19
title_full_unstemmed A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19
title_short A new threshold reveals the uncertainty about the effect of school opening on diffusion of Covid-19
title_sort new threshold reveals the uncertainty about the effect of school opening on diffusion of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863853/
https://www.ncbi.nlm.nih.gov/pubmed/35194065
http://dx.doi.org/10.1038/s41598-022-06540-w
work_keys_str_mv AT gandolfialberto anewthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT aspriandrea anewthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT berettaelena anewthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT jamshadkhola anewthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT jiangmuyan anewthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT gandolfialberto newthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT aspriandrea newthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT berettaelena newthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT jamshadkhola newthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19
AT jiangmuyan newthresholdrevealstheuncertaintyabouttheeffectofschoolopeningondiffusionofcovid19