Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy

Cisplatin (DDP) resistance is an important factor that decreases the effect of chemotherapy, thus leading to local recurrence and lymph node metastasis of hypopharyngeal squamous cell carcinoma (HSCC). We aimed to explore the role and mechanism of extrachromosomal circular DNA (eccDNA) in the DDP re...

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Detalles Bibliográficos
Autores principales: Lin, Changwei, Chen, Yifei, Zhang, Fan, Liu, Baiying, Xie, Canbin, Song, Yexun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863882/
https://www.ncbi.nlm.nih.gov/pubmed/35194030
http://dx.doi.org/10.1038/s41419-022-04627-w

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