Cargando…

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ning, Qin, Wu, Di, Wang, Xiaojing, Xi, Dong, Chen, Tao, Chen, Guang, Wang, Hongwu, Lu, Huiling, Wang, Ming, Zhu, Lin, Hu, Junjian, Liu, Tingting, Ma, Ke, Han, Meifang, Luo, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863906/
https://www.ncbi.nlm.nih.gov/pubmed/35197452
http://dx.doi.org/10.1038/s41392-022-00907-1
_version_ 1784655336339144704
author Ning, Qin
Wu, Di
Wang, Xiaojing
Xi, Dong
Chen, Tao
Chen, Guang
Wang, Hongwu
Lu, Huiling
Wang, Ming
Zhu, Lin
Hu, Junjian
Liu, Tingting
Ma, Ke
Han, Meifang
Luo, Xiaoping
author_facet Ning, Qin
Wu, Di
Wang, Xiaojing
Xi, Dong
Chen, Tao
Chen, Guang
Wang, Hongwu
Lu, Huiling
Wang, Ming
Zhu, Lin
Hu, Junjian
Liu, Tingting
Ma, Ke
Han, Meifang
Luo, Xiaoping
author_sort Ning, Qin
collection PubMed
description The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.
format Online
Article
Text
id pubmed-8863906
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-88639062022-02-23 The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication Ning, Qin Wu, Di Wang, Xiaojing Xi, Dong Chen, Tao Chen, Guang Wang, Hongwu Lu, Huiling Wang, Ming Zhu, Lin Hu, Junjian Liu, Tingting Ma, Ke Han, Meifang Luo, Xiaoping Signal Transduct Target Ther Review Article The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19. Nature Publishing Group UK 2022-02-23 /pmc/articles/PMC8863906/ /pubmed/35197452 http://dx.doi.org/10.1038/s41392-022-00907-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Ning, Qin
Wu, Di
Wang, Xiaojing
Xi, Dong
Chen, Tao
Chen, Guang
Wang, Hongwu
Lu, Huiling
Wang, Ming
Zhu, Lin
Hu, Junjian
Liu, Tingting
Ma, Ke
Han, Meifang
Luo, Xiaoping
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
title The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
title_full The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
title_fullStr The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
title_full_unstemmed The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
title_short The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
title_sort mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863906/
https://www.ncbi.nlm.nih.gov/pubmed/35197452
http://dx.doi.org/10.1038/s41392-022-00907-1
work_keys_str_mv AT ningqin themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wudi themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wangxiaojing themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT xidong themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT chentao themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT chenguang themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wanghongwu themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT luhuiling themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wangming themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT zhulin themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT hujunjian themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT liutingting themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT make themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT hanmeifang themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT luoxiaoping themechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT ningqin mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wudi mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wangxiaojing mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT xidong mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT chentao mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT chenguang mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wanghongwu mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT luhuiling mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT wangming mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT zhulin mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT hujunjian mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT liutingting mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT make mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT hanmeifang mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication
AT luoxiaoping mechanismunderlyingextrapulmonarycomplicationsofthecoronavirusdisease2019anditstherapeuticimplication