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The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index

The central arteries dampen the pulsatile forces from myocardial contraction, limiting the pulsatility that reaches the cerebral vasculature, although there are limited data on this relationship with aging in humans. The purpose of this study was to determine the association between aortic stiffness...

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Autores principales: Fico, Brandon G., Miller, Kathleen B., Rivera-Rivera, Leonardo A., Corkery, Adam T., Pearson, Andrew G., Eisenmann, Nicole A., Howery, Anna J., Rowley, Howard A., Johnson, Kevin M., Johnson, Sterling C., Wieben, Oliver, Barnes, Jill N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863930/
https://www.ncbi.nlm.nih.gov/pubmed/35224051
http://dx.doi.org/10.3389/fcvm.2022.821151
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author Fico, Brandon G.
Miller, Kathleen B.
Rivera-Rivera, Leonardo A.
Corkery, Adam T.
Pearson, Andrew G.
Eisenmann, Nicole A.
Howery, Anna J.
Rowley, Howard A.
Johnson, Kevin M.
Johnson, Sterling C.
Wieben, Oliver
Barnes, Jill N.
author_facet Fico, Brandon G.
Miller, Kathleen B.
Rivera-Rivera, Leonardo A.
Corkery, Adam T.
Pearson, Andrew G.
Eisenmann, Nicole A.
Howery, Anna J.
Rowley, Howard A.
Johnson, Kevin M.
Johnson, Sterling C.
Wieben, Oliver
Barnes, Jill N.
author_sort Fico, Brandon G.
collection PubMed
description The central arteries dampen the pulsatile forces from myocardial contraction, limiting the pulsatility that reaches the cerebral vasculature, although there are limited data on this relationship with aging in humans. The purpose of this study was to determine the association between aortic stiffness and cerebral artery pulsatility index in young and older adults. We hypothesized that cerebral pulsatility index would be associated with aortic stiffness in older adults, but not in young adults. We also hypothesized that both age and aortic stiffness would be significant predictors for cerebral pulsatility index. This study included 23 healthy older adults (aged 62 ± 6 years) and 33 healthy young adults (aged 25 ± 4 years). Aortic stiffness was measured using carotid-femoral pulse wave velocity (cfPWV), while cerebral artery pulsatility index in the internal carotid arteries (ICAs), middle cerebral arteries (MCAs), and basilar artery were assessed using 4D Flow MRI. Cerebral pulsatility index was calculated as (maximum flow – minimum flow) / mean flow. In the combined age group, there was a positive association between cfPWV and cerebral pulsatility index in the ICAs (r = 0.487; p < 0.001), MCAs (r = 0.393; p = 0.003), and basilar artery (r = 0.576; p < 0.001). In young adults, there were no associations between cfPWV and cerebral pulsatility index in any of the arteries of interest (ICAs: r = 0.253; p = 0.156, MCAs: r = −0.059; p = 0.743, basilar artery r = 0.171; p = 0.344). In contrast, in older adults there was a positive association between cfPWV and cerebral pulsatility index in the MCAs (r = 0.437; p = 0.037) and basilar artery (r = 0.500; p = 0.015). However, the relationship between cfPWV and cerebral pulsatility index in the ICAs of the older adults did not reach the threshold for significance (r = 0.375; p = 0.078). In conclusion, age and aortic stiffness are significant predictors of cerebral artery pulsatility index in healthy adults. This study highlights the importance of targeting aortic stiffness in our increasingly aging population to reduce the burden of age-related changes in cerebral hemodynamics.
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spelling pubmed-88639302022-02-24 The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index Fico, Brandon G. Miller, Kathleen B. Rivera-Rivera, Leonardo A. Corkery, Adam T. Pearson, Andrew G. Eisenmann, Nicole A. Howery, Anna J. Rowley, Howard A. Johnson, Kevin M. Johnson, Sterling C. Wieben, Oliver Barnes, Jill N. Front Cardiovasc Med Cardiovascular Medicine The central arteries dampen the pulsatile forces from myocardial contraction, limiting the pulsatility that reaches the cerebral vasculature, although there are limited data on this relationship with aging in humans. The purpose of this study was to determine the association between aortic stiffness and cerebral artery pulsatility index in young and older adults. We hypothesized that cerebral pulsatility index would be associated with aortic stiffness in older adults, but not in young adults. We also hypothesized that both age and aortic stiffness would be significant predictors for cerebral pulsatility index. This study included 23 healthy older adults (aged 62 ± 6 years) and 33 healthy young adults (aged 25 ± 4 years). Aortic stiffness was measured using carotid-femoral pulse wave velocity (cfPWV), while cerebral artery pulsatility index in the internal carotid arteries (ICAs), middle cerebral arteries (MCAs), and basilar artery were assessed using 4D Flow MRI. Cerebral pulsatility index was calculated as (maximum flow – minimum flow) / mean flow. In the combined age group, there was a positive association between cfPWV and cerebral pulsatility index in the ICAs (r = 0.487; p < 0.001), MCAs (r = 0.393; p = 0.003), and basilar artery (r = 0.576; p < 0.001). In young adults, there were no associations between cfPWV and cerebral pulsatility index in any of the arteries of interest (ICAs: r = 0.253; p = 0.156, MCAs: r = −0.059; p = 0.743, basilar artery r = 0.171; p = 0.344). In contrast, in older adults there was a positive association between cfPWV and cerebral pulsatility index in the MCAs (r = 0.437; p = 0.037) and basilar artery (r = 0.500; p = 0.015). However, the relationship between cfPWV and cerebral pulsatility index in the ICAs of the older adults did not reach the threshold for significance (r = 0.375; p = 0.078). In conclusion, age and aortic stiffness are significant predictors of cerebral artery pulsatility index in healthy adults. This study highlights the importance of targeting aortic stiffness in our increasingly aging population to reduce the burden of age-related changes in cerebral hemodynamics. Frontiers Media S.A. 2022-02-09 /pmc/articles/PMC8863930/ /pubmed/35224051 http://dx.doi.org/10.3389/fcvm.2022.821151 Text en Copyright © 2022 Fico, Miller, Rivera-Rivera, Corkery, Pearson, Eisenmann, Howery, Rowley, Johnson, Johnson, Wieben and Barnes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Fico, Brandon G.
Miller, Kathleen B.
Rivera-Rivera, Leonardo A.
Corkery, Adam T.
Pearson, Andrew G.
Eisenmann, Nicole A.
Howery, Anna J.
Rowley, Howard A.
Johnson, Kevin M.
Johnson, Sterling C.
Wieben, Oliver
Barnes, Jill N.
The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index
title The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index
title_full The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index
title_fullStr The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index
title_full_unstemmed The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index
title_short The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index
title_sort impact of aging on the association between aortic stiffness and cerebral pulsatility index
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863930/
https://www.ncbi.nlm.nih.gov/pubmed/35224051
http://dx.doi.org/10.3389/fcvm.2022.821151
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