Cargando…

Glioblastoma, IDH-Wild Type With FGFR3-TACC3 Fusion: When Morphology May Reliably Predict the Molecular Profile of a Tumor. A Case Report and Literature Review

It has been reported that in-frame FGFR3-TACC3 fusions confer to glioblastomas, IDH-wild type (GBMs, IDHwt) some unusual morphologic features, including monomorphous rounded cells with ovoid nuclei, nuclear palisading, endocrinoid network of “chicken-wire” vessels, microcalcifications and desmoplast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Broggi, Giuseppe, Piombino, Eliana, Altieri, Roberto, Romano, Chiara, Certo, Francesco, Barbagallo, Giuseppe Maria Vincenzo, Vigneri, Paolo, Condorelli, Dario, Colarossi, Lorenzo, Colarossi, Cristina, Magro, Gaetano, Tirrò, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863931/ https://www.ncbi.nlm.nih.gov/pubmed/35222252 http://dx.doi.org/10.3389/fneur.2022.823015

Ejemplares similares

Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions
por: Mata, Douglas A., et al.
Publicado: (2020)

Histologic Definition of Enhancing Core and FLAIR Hyperintensity Region of Glioblastoma, IDH-Wild Type: A Clinico-Pathologic Study on a Single-Institution Series
por: Broggi, Giuseppe, et al.
Publicado: (2023)

A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas
por: Failla, Maria, et al.
Publicado: (2022)

FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human Glioblastoma
por: Gött, Hanna, et al.
Publicado: (2022)

A Custom DNA-Based NGS Panel for the Molecular Characterization of Patients With Diffuse Gliomas: Diagnostic and Therapeutic Applications
por: Tirrò, Elena, et al.
Publicado: (2022)

Immunoexpression of p62/SQSTM1/Sequestosome-1 in human primary and recurrent IDH1/2 wild-type glioblastoma: A pilot study
por: Ieni, Antonio, et al.
Publicado: (2022)

FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium
por: Best, Sarah A., et al.
Publicado: (2018)

FGFR3-TACC3 fusion in solid tumors: mini review
por: Costa, Ricardo, et al.
Publicado: (2016)

Sclerosing Mesenteritis, a Rare Cause of Mesenteric Mass in a Young Adult: A Case Report
por: Piombino, Eliana, et al.
Publicado: (2021)

FGFR3–TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle
por: Sarkar, Sourav, et al.
Publicado: (2017)

FGFR3–TACC3: A novel gene fusion in cervical cancer
por: Carneiro, Benedito A., et al.
Publicado: (2015)

A metabolic function of FGFR3-TACC3 gene fusions in cancer
por: Frattini, Véronique, et al.
Publicado: (2018)

Diagnostic Utility of the Immunohistochemical Expression of Serine and Arginine Rich Splicing Factor 1 (SRSF1) in the Differential Diagnosis of Adult Gliomas
por: Broggi, Giuseppe, et al.
Publicado: (2021)

Coexisting FGFR3 p.K650T mutation in two FGFR3-TACC3 fusion glioma cases
por: Ballester, Leomar Y., et al.
Publicado: (2019)

Peritumoral Microenvironment in High-Grade Gliomas: From FLAIRectomy to Microglia–Glioma Cross-Talk
por: Altieri, Roberto, et al.
Publicado: (2021)

Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions
por: Tamura, Ryo, et al.
Publicado: (2018)

Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling
por: Nelson, Katelyn N., et al.
Publicado: (2018)

Clinico-pathological and epigenetic heterogeneity of diffuse gliomas with FGFR3::TACC3 fusion
por: Métais, Alice, et al.
Publicado: (2023)

circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets, Insulin-like Growth Factor Binding Protein 2 (IGFBP2) and NRAS Proto-Oncogene, GTPase (NRAS) in Glioblastoma
por: Merulla, Aurora Eliana, et al.
Publicado: (2022)

RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine
por: Parker Kerrigan, Brittany C, et al.
Publicado: (2020)

Medullary Carcinoma of the Gastrointestinal Tract: Report on Two Cases with Immunohistochemical and Molecular Features
por: Colarossi, Cristina, et al.
Publicado: (2021)

Serum Extracellular Vesicle-Derived circHIPK3 and circSMARCA5 Are Two Novel Diagnostic Biomarkers for Glioblastoma Multiforme
por: Stella, Michele, et al.
Publicado: (2021)

Solitary fibrous tumor with atypical features of the paravesical space: benign clinical course at the 10-years follow-up. Report of a case and review of the literature
por: Magro, Gaetano, et al.
Publicado: (2020)

A “polymorphous low-grade neuroepithelial tumor of the young (PLNTY)” diagnosed in an adult. Report of a case and review of the literature
por: Broggi, Giuseppe, et al.
Publicado: (2021)

Aberrations of TACC1 and TACC3 are associated with ovarian cancer
por: Lauffart, Brenda, et al.
Publicado: (2005)

Development of RNA-FISH Assay for Detection of Oncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples
por: Kurobe, Masahiro, et al.
Publicado: (2016)

Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis
por: Lombardi, Benedetta, et al.
Publicado: (2017)

Regional Development of Glioblastoma: The Anatomical Conundrum of Cancer Biology and Its Surgical Implication
por: De Luca, Ciro, et al.
Publicado: (2022)

TACC3 in personalized medicine
por: Murata, Stephen, et al.
Publicado: (2015)

Wilms’ Tumor 1 (WT1): A Novel Immunomarker of Dermatofibrosarcoma Protuberans—An Immunohistochemical Study on a Series of 114 Cases of Bland-Looking Mesenchymal Spindle Cell Lesions of the Dermis/Subcutaneous Tissues
por: Piombino, Eliana, et al.
Publicado: (2021)

Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability
por: Wang, Clark G., et al.
Publicado: (2023)

Successful Treatment and Retreatment With Erdafitinib for a Patient With FGFR3-TACC3 Fusion Squamous NSCLC: A Case Report
por: Pham, Chi, et al.
Publicado: (2023)

A Case of Foramen Magnum and C1–C2 Meningiomas: Double Challenge, One Approach
por: Toccaceli, Giada, et al.
Publicado: (2021)

Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes
por: Duncan, Christopher G., et al.
Publicado: (2010)

FGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling
por: Daly, C, et al.
Publicado: (2017)

Brain Metastases from Breast Cancer Histologically Exhibit Solid Growth Pattern with at Least Focal Comedonecrosis: A Histopathologic Study on a Monocentric Series of 30 Cases
por: Farina, Jessica, et al.
Publicado: (2023)

The GAUGAA Motif Is Responsible for the Binding between circSMARCA5 and SRSF1 and Related Downstream Effects on Glioblastoma Multiforme Cell Migration and Angiogenic Potential
por: Barbagallo, Davide, et al.
Publicado: (2021)

Endomyometriosis of the Rectum With Disseminated Peritoneal Leiomyomatosis 8 Years After Laparoscopic Myomectomy: A Case Report
por: La Greca, Giorgio, et al.
Publicado: (2021)

Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview
por: Angelico, Giuseppe, et al.
Publicado: (2022)

Thalamomesencephalic cavernoma: anterior transcallosal transchoroidal approach
por: Certo, Francesco, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fot67cvni5v2t1dvl8ghracgo1