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White matter myelination during early infancy is linked to spatial gradients and myelin content at birth
Development of myelin, a fatty sheath that insulates nerve fibers, is critical for brain function. Myelination during infancy has been studied with histology, but postmortem data cannot evaluate the longitudinal trajectory of white matter development. Here, we obtained longitudinal diffusion MRI and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863985/ https://www.ncbi.nlm.nih.gov/pubmed/35194018 http://dx.doi.org/10.1038/s41467-022-28326-4 |
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author | Grotheer, Mareike Rosenke, Mona Wu, Hua Kular, Holly Querdasi, Francesca R. Natu, Vaidehi S. Yeatman, Jason D. Grill-Spector, Kalanit |
author_facet | Grotheer, Mareike Rosenke, Mona Wu, Hua Kular, Holly Querdasi, Francesca R. Natu, Vaidehi S. Yeatman, Jason D. Grill-Spector, Kalanit |
author_sort | Grotheer, Mareike |
collection | PubMed |
description | Development of myelin, a fatty sheath that insulates nerve fibers, is critical for brain function. Myelination during infancy has been studied with histology, but postmortem data cannot evaluate the longitudinal trajectory of white matter development. Here, we obtained longitudinal diffusion MRI and quantitative MRI measures of longitudinal relaxation rate (R1) of white matter in 0, 3 and 6 months-old human infants, and developed an automated method to identify white matter bundles and quantify their properties in each infant’s brain. We find that R1 increases from newborns to 6-months-olds in all bundles. R1 development is nonuniform: there is faster development in white matter that is less mature in newborns, and development rate increases along inferior-to-superior as well as anterior-to-posterior spatial gradients. As R1 is linearly related to myelin fraction in white matter bundles, these findings open new avenues to elucidate typical and atypical white matter myelination in early infancy. |
format | Online Article Text |
id | pubmed-8863985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88639852022-03-17 White matter myelination during early infancy is linked to spatial gradients and myelin content at birth Grotheer, Mareike Rosenke, Mona Wu, Hua Kular, Holly Querdasi, Francesca R. Natu, Vaidehi S. Yeatman, Jason D. Grill-Spector, Kalanit Nat Commun Article Development of myelin, a fatty sheath that insulates nerve fibers, is critical for brain function. Myelination during infancy has been studied with histology, but postmortem data cannot evaluate the longitudinal trajectory of white matter development. Here, we obtained longitudinal diffusion MRI and quantitative MRI measures of longitudinal relaxation rate (R1) of white matter in 0, 3 and 6 months-old human infants, and developed an automated method to identify white matter bundles and quantify their properties in each infant’s brain. We find that R1 increases from newborns to 6-months-olds in all bundles. R1 development is nonuniform: there is faster development in white matter that is less mature in newborns, and development rate increases along inferior-to-superior as well as anterior-to-posterior spatial gradients. As R1 is linearly related to myelin fraction in white matter bundles, these findings open new avenues to elucidate typical and atypical white matter myelination in early infancy. Nature Publishing Group UK 2022-02-22 /pmc/articles/PMC8863985/ /pubmed/35194018 http://dx.doi.org/10.1038/s41467-022-28326-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Grotheer, Mareike Rosenke, Mona Wu, Hua Kular, Holly Querdasi, Francesca R. Natu, Vaidehi S. Yeatman, Jason D. Grill-Spector, Kalanit White matter myelination during early infancy is linked to spatial gradients and myelin content at birth |
title | White matter myelination during early infancy is linked to spatial gradients and myelin content at birth |
title_full | White matter myelination during early infancy is linked to spatial gradients and myelin content at birth |
title_fullStr | White matter myelination during early infancy is linked to spatial gradients and myelin content at birth |
title_full_unstemmed | White matter myelination during early infancy is linked to spatial gradients and myelin content at birth |
title_short | White matter myelination during early infancy is linked to spatial gradients and myelin content at birth |
title_sort | white matter myelination during early infancy is linked to spatial gradients and myelin content at birth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863985/ https://www.ncbi.nlm.nih.gov/pubmed/35194018 http://dx.doi.org/10.1038/s41467-022-28326-4 |
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