Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common familial form of stroke, which is caused by mutations located in the epidermal growth factor (EGF)-like repeats of the NOTCH3 gene. Mutations cause the NOTCH3 (N3) protein to misfo...

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Detalles Bibliográficos
Autores principales: Oliveira, Daniel V., Svensson, Julia, Zhong, Xueying, Biverstål, Henrik, Chen, Gefei, Karlström, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864064/
https://www.ncbi.nlm.nih.gov/pubmed/35223989
http://dx.doi.org/10.3389/fmolb.2022.812808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864064/
https://www.ncbi.nlm.nih.gov/pubmed/35223989
http://dx.doi.org/10.3389/fmolb.2022.812808

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