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Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer

Breast cancer is the most common malignant tumor in women. Researchers have found that the combined use of multiple methods to treat tumors is a promising strategy. Here, we have developed a biomimetic nano-platform PDA@MB for tumor targeted photothermal therapy (PTT) combined with chemotherapy. The...

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Autores principales: Leng, Junke, Dai, Xiaofeng, Cheng, Xiao, Zhou, Hao, Wang, Dong, Zhao, Jing, Ma, Kun, Cui, Changhao, Wang, Li, Guo, Zhaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864241/
https://www.ncbi.nlm.nih.gov/pubmed/35223801
http://dx.doi.org/10.3389/fbioe.2022.841186
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author Leng, Junke
Dai, Xiaofeng
Cheng, Xiao
Zhou, Hao
Wang, Dong
Zhao, Jing
Ma, Kun
Cui, Changhao
Wang, Li
Guo, Zhaoming
author_facet Leng, Junke
Dai, Xiaofeng
Cheng, Xiao
Zhou, Hao
Wang, Dong
Zhao, Jing
Ma, Kun
Cui, Changhao
Wang, Li
Guo, Zhaoming
author_sort Leng, Junke
collection PubMed
description Breast cancer is the most common malignant tumor in women. Researchers have found that the combined use of multiple methods to treat tumors is a promising strategy. Here, we have developed a biomimetic nano-platform PDA@MB for tumor targeted photothermal therapy (PTT) combined with chemotherapy. The 4T1 cell membrane loaded with cucurbitacin B (CuB) was used to coat polydopamine (PDA) nanoparticles, which gave PDA@MB nanoparticles the ability to target tumors and escape immune cells from phagocytosis. PDA@MB showed excellent photothermal performance including high photothermal conversion efficiency and photostability, and exhibited outstanding in vitro PTT effect under NIR laser irradiation. The high temperature ruptured the PDA@MB membrane to release CuB, which changed the tumor hypoxic environment, down-regulated the FAK/MMP signaling pathway, and significantly inhibited the metastasis and proliferation of tumor cells. The results of in vivo experiments indicated that the tumor growth of the 4T1 mouse tumor model was significantly inhibited. Additionally, toxicity studies showed that PDA@MB had good biocompatibility and safety. In conclusion, this study provides a promising chemo-photothermal therapy (CPT) nano-platform for precise and effective breast cancer therapy.
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spelling pubmed-88642412022-02-24 Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer Leng, Junke Dai, Xiaofeng Cheng, Xiao Zhou, Hao Wang, Dong Zhao, Jing Ma, Kun Cui, Changhao Wang, Li Guo, Zhaoming Front Bioeng Biotechnol Bioengineering and Biotechnology Breast cancer is the most common malignant tumor in women. Researchers have found that the combined use of multiple methods to treat tumors is a promising strategy. Here, we have developed a biomimetic nano-platform PDA@MB for tumor targeted photothermal therapy (PTT) combined with chemotherapy. The 4T1 cell membrane loaded with cucurbitacin B (CuB) was used to coat polydopamine (PDA) nanoparticles, which gave PDA@MB nanoparticles the ability to target tumors and escape immune cells from phagocytosis. PDA@MB showed excellent photothermal performance including high photothermal conversion efficiency and photostability, and exhibited outstanding in vitro PTT effect under NIR laser irradiation. The high temperature ruptured the PDA@MB membrane to release CuB, which changed the tumor hypoxic environment, down-regulated the FAK/MMP signaling pathway, and significantly inhibited the metastasis and proliferation of tumor cells. The results of in vivo experiments indicated that the tumor growth of the 4T1 mouse tumor model was significantly inhibited. Additionally, toxicity studies showed that PDA@MB had good biocompatibility and safety. In conclusion, this study provides a promising chemo-photothermal therapy (CPT) nano-platform for precise and effective breast cancer therapy. Frontiers Media S.A. 2022-02-09 /pmc/articles/PMC8864241/ /pubmed/35223801 http://dx.doi.org/10.3389/fbioe.2022.841186 Text en Copyright © 2022 Leng, Dai, Cheng, Zhou, Wang, Zhao, Ma, Cui, Wang and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Leng, Junke
Dai, Xiaofeng
Cheng, Xiao
Zhou, Hao
Wang, Dong
Zhao, Jing
Ma, Kun
Cui, Changhao
Wang, Li
Guo, Zhaoming
Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer
title Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer
title_full Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer
title_fullStr Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer
title_full_unstemmed Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer
title_short Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer
title_sort biomimetic cucurbitacin b-polydopamine nanoparticles for synergistic chemo-photothermal therapy of breast cancer
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864241/
https://www.ncbi.nlm.nih.gov/pubmed/35223801
http://dx.doi.org/10.3389/fbioe.2022.841186
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