Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis

A 40-year-old man presented at our hospital with anaemia that had been undiagnosed for 2 years. Blood tests, endoscopy, and contrast-enhanced computed tomography were performed, but a definitive diagnosis could not be made. A subsequent bone marrow biopsy revealed basophilic stippling in transformed...

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Autores principales: Kano, Nagamasa, Fukui, Sayato, Kushiro, Seiko, Inui, Akihiro, Saita, Mizue, Kura, Yoshimasa, Sawada, Umihiko, Naito, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864261/
https://www.ncbi.nlm.nih.gov/pubmed/35184610
http://dx.doi.org/10.1177/03000605221078405
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author Kano, Nagamasa
Fukui, Sayato
Kushiro, Seiko
Inui, Akihiro
Saita, Mizue
Kura, Yoshimasa
Sawada, Umihiko
Naito, Toshio
author_facet Kano, Nagamasa
Fukui, Sayato
Kushiro, Seiko
Inui, Akihiro
Saita, Mizue
Kura, Yoshimasa
Sawada, Umihiko
Naito, Toshio
author_sort Kano, Nagamasa
collection PubMed
description A 40-year-old man presented at our hospital with anaemia that had been undiagnosed for 2 years. Blood tests, endoscopy, and contrast-enhanced computed tomography were performed, but a definitive diagnosis could not be made. A subsequent bone marrow biopsy revealed basophilic stippling in transformed red blood cells, which led to a differential diagnosis of lead poisoning. Additional tests revealed elevated levels of lead in the blood. Basophilic stippling is generally found on a peripheral blood smear in lead poisoning patients; however, in this case, basophilic stippling was found only on the bone marrow smear and not in the blood smear. Even if basophilic stippling is not found in the peripheral blood, lead poisoning cannot be excluded.
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spelling pubmed-88642612022-02-24 Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis Kano, Nagamasa Fukui, Sayato Kushiro, Seiko Inui, Akihiro Saita, Mizue Kura, Yoshimasa Sawada, Umihiko Naito, Toshio J Int Med Res Case Reports A 40-year-old man presented at our hospital with anaemia that had been undiagnosed for 2 years. Blood tests, endoscopy, and contrast-enhanced computed tomography were performed, but a definitive diagnosis could not be made. A subsequent bone marrow biopsy revealed basophilic stippling in transformed red blood cells, which led to a differential diagnosis of lead poisoning. Additional tests revealed elevated levels of lead in the blood. Basophilic stippling is generally found on a peripheral blood smear in lead poisoning patients; however, in this case, basophilic stippling was found only on the bone marrow smear and not in the blood smear. Even if basophilic stippling is not found in the peripheral blood, lead poisoning cannot be excluded. SAGE Publications 2022-02-20 /pmc/articles/PMC8864261/ /pubmed/35184610 http://dx.doi.org/10.1177/03000605221078405 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Kano, Nagamasa
Fukui, Sayato
Kushiro, Seiko
Inui, Akihiro
Saita, Mizue
Kura, Yoshimasa
Sawada, Umihiko
Naito, Toshio
Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis
title Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis
title_full Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis
title_fullStr Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis
title_full_unstemmed Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis
title_short Basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis
title_sort basophilic stippling in red blood cells in the bone marrow: indication for lead poisoning diagnosis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864261/
https://www.ncbi.nlm.nih.gov/pubmed/35184610
http://dx.doi.org/10.1177/03000605221078405
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