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Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine

Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorb...

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Autores principales: Evans, Nicholas R, Todd, Oliver M, Minhas, Jatinder S, Fearon, Patricia, Harston, George W, Mant, Jonathan, Mead, Gillian, Hewitt, Jonathan, Quinn, Terence J, Warburton, Elizabeth A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864332/
https://www.ncbi.nlm.nih.gov/pubmed/34282986
http://dx.doi.org/10.1177/17474930211034331
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author Evans, Nicholas R
Todd, Oliver M
Minhas, Jatinder S
Fearon, Patricia
Harston, George W
Mant, Jonathan
Mead, Gillian
Hewitt, Jonathan
Quinn, Terence J
Warburton, Elizabeth A
author_facet Evans, Nicholas R
Todd, Oliver M
Minhas, Jatinder S
Fearon, Patricia
Harston, George W
Mant, Jonathan
Mead, Gillian
Hewitt, Jonathan
Quinn, Terence J
Warburton, Elizabeth A
author_sort Evans, Nicholas R
collection PubMed
description Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings.
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spelling pubmed-88643322022-02-24 Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine Evans, Nicholas R Todd, Oliver M Minhas, Jatinder S Fearon, Patricia Harston, George W Mant, Jonathan Mead, Gillian Hewitt, Jonathan Quinn, Terence J Warburton, Elizabeth A Int J Stroke Review Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings. SAGE Publications 2021-08-04 2022-03 /pmc/articles/PMC8864332/ /pubmed/34282986 http://dx.doi.org/10.1177/17474930211034331 Text en © 2021 World Stroke Organization https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Evans, Nicholas R
Todd, Oliver M
Minhas, Jatinder S
Fearon, Patricia
Harston, George W
Mant, Jonathan
Mead, Gillian
Hewitt, Jonathan
Quinn, Terence J
Warburton, Elizabeth A
Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine
title Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine
title_full Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine
title_fullStr Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine
title_full_unstemmed Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine
title_short Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine
title_sort frailty and cerebrovascular disease: concepts and clinical implications for stroke medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864332/
https://www.ncbi.nlm.nih.gov/pubmed/34282986
http://dx.doi.org/10.1177/17474930211034331
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