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Constrained optimization of divisional load in hierarchically organized tissues during homeostasis
It has been hypothesized that the structure of tissues and the hierarchy of differentiation from stem cell to terminally differentiated cell play a significant role in reducing the incidence of cancer in that tissue. One specific mechanism by which this risk can be reduced is by minimizing the numbe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864360/ https://www.ncbi.nlm.nih.gov/pubmed/35193391 http://dx.doi.org/10.1098/rsif.2021.0784 |