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Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature
BACKGROUND: Neisseria meningitidis is an encapsulated Gram-negative diplococcus that asymptomatically colonises the upper respiratory tract in up to 25% of the population (mainly adolescents and young adults). Invasive meningococcal disease (IMD) caused by Neisseria meningitidis imposes a substantia...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864456/ https://www.ncbi.nlm.nih.gov/pubmed/35197024 http://dx.doi.org/10.1186/s12889-022-12795-9 |
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author | Guedes, Sandra Bertrand-Gerentes, Isabelle Evans, Keith Coste, Florence Oster, Philipp |
author_facet | Guedes, Sandra Bertrand-Gerentes, Isabelle Evans, Keith Coste, Florence Oster, Philipp |
author_sort | Guedes, Sandra |
collection | PubMed |
description | BACKGROUND: Neisseria meningitidis is an encapsulated Gram-negative diplococcus that asymptomatically colonises the upper respiratory tract in up to 25% of the population (mainly adolescents and young adults). Invasive meningococcal disease (IMD) caused by Neisseria meningitidis imposes a substantial public health burden,. The case fatality rate (CFR) of IMD remains high. IMD epidemiology varies markedly by region and over time, and there appears to be a shift in the epidemiology towards older adults. The objective of our review was to assess the published data on the epidemiology of IMD in older adults (those aged ≥ 55 years)in North America and Europe. Such information would assist decision-makers at national and international levels in developing future public health programmes for managing IMD. METHODS: A comprehensive literature review was undertaken on 11 August 2020 across three databases: EMBASE, Medline and BIOSIS. Papers were included if they met the following criteria: full paper written in the English language; included patients aged ≥ 56 years; were published between 1/1/2009 11/9/2020 and included patients with either suspected or confirmed IMD or infection with N. meningitidis in North America or Europe. Case studies/reports/series were eligible for inclusion if they included persons in the age range of interest. Animal studies and letters to editors were excluded. In addition, the websites of international and national organisations and societies were also checked for relevant information. RESULTS: There were 5,364 citations identified in total, of which 76 publications were included in this review. We identified that older adults with IMD were mainly affected by serogroups W and Y, which are generally not the predominant strains in circulation in most countries. Older adults had the highest CFRs, probably linked to underlying comorbidities and more atypical presentations hindering appropriate timely management. In addition, there was some evidence of a shift in the incidence of IMD from younger to older adults. CONCLUSIONS: The use of meningococcal vaccines that include coverage against serogroups W and Y in immunization programs for older adults needs to be evaluated to inform health authorities’ decisions of the relative benefits of vaccination and the utility of expanding national immunization programmes to this age group. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-022-12795-9. |
format | Online Article Text |
id | pubmed-8864456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-88644562022-02-23 Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature Guedes, Sandra Bertrand-Gerentes, Isabelle Evans, Keith Coste, Florence Oster, Philipp BMC Public Health Research BACKGROUND: Neisseria meningitidis is an encapsulated Gram-negative diplococcus that asymptomatically colonises the upper respiratory tract in up to 25% of the population (mainly adolescents and young adults). Invasive meningococcal disease (IMD) caused by Neisseria meningitidis imposes a substantial public health burden,. The case fatality rate (CFR) of IMD remains high. IMD epidemiology varies markedly by region and over time, and there appears to be a shift in the epidemiology towards older adults. The objective of our review was to assess the published data on the epidemiology of IMD in older adults (those aged ≥ 55 years)in North America and Europe. Such information would assist decision-makers at national and international levels in developing future public health programmes for managing IMD. METHODS: A comprehensive literature review was undertaken on 11 August 2020 across three databases: EMBASE, Medline and BIOSIS. Papers were included if they met the following criteria: full paper written in the English language; included patients aged ≥ 56 years; were published between 1/1/2009 11/9/2020 and included patients with either suspected or confirmed IMD or infection with N. meningitidis in North America or Europe. Case studies/reports/series were eligible for inclusion if they included persons in the age range of interest. Animal studies and letters to editors were excluded. In addition, the websites of international and national organisations and societies were also checked for relevant information. RESULTS: There were 5,364 citations identified in total, of which 76 publications were included in this review. We identified that older adults with IMD were mainly affected by serogroups W and Y, which are generally not the predominant strains in circulation in most countries. Older adults had the highest CFRs, probably linked to underlying comorbidities and more atypical presentations hindering appropriate timely management. In addition, there was some evidence of a shift in the incidence of IMD from younger to older adults. CONCLUSIONS: The use of meningococcal vaccines that include coverage against serogroups W and Y in immunization programs for older adults needs to be evaluated to inform health authorities’ decisions of the relative benefits of vaccination and the utility of expanding national immunization programmes to this age group. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-022-12795-9. BioMed Central 2022-02-23 /pmc/articles/PMC8864456/ /pubmed/35197024 http://dx.doi.org/10.1186/s12889-022-12795-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Guedes, Sandra Bertrand-Gerentes, Isabelle Evans, Keith Coste, Florence Oster, Philipp Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature |
title | Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature |
title_full | Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature |
title_fullStr | Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature |
title_full_unstemmed | Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature |
title_short | Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature |
title_sort | invasive meningococcal disease in older adults in north america and europe: is this the time for action? a review of the literature |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864456/ https://www.ncbi.nlm.nih.gov/pubmed/35197024 http://dx.doi.org/10.1186/s12889-022-12795-9 |
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