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Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities

The combination cancer immunotherapies with oncolytic virus (OV) and immune checkpoint blockade (ICB) reinstate otherwise dysfunctional antitumor CD8 T cell responses. One major mechanism that aids such reinstatement of antitumor CD8 T cells involves the availability of new class I major histocompat...

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Detalles Bibliográficos
Autores principales:	Kim, Youra, Konda, Prathyusha, Murphy, J. Patrick, Paulo, Joao A., Gygi, Steven P., Gujar, Shashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864471/ https://www.ncbi.nlm.nih.gov/pubmed/34922008 http://dx.doi.org/10.1016/j.mcpro.2021.100182

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