Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain

A number of tricyclic antidepressants (TCAs) are commonly prescribed off-label for the treatment of neuropathic pain. The blockade of neuronal calcium ion channels is often invoked to partially explain the analgesic activity of TCAs, but there has been very limited experimental or theoretical eviden...

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Detalles Bibliográficos
Autores principales: Cardoso, Fernanda C., Schmit, Matthieu, Kuiper, Michael J., Lewis, Richard J., Tuck, Kellie L., Duggan, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864487/
https://www.ncbi.nlm.nih.gov/pubmed/35308021
http://dx.doi.org/10.1039/d1md00331c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864487/
https://www.ncbi.nlm.nih.gov/pubmed/35308021
http://dx.doi.org/10.1039/d1md00331c

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