Cargando…

The stalk domain of SARS-CoV-2 NSP13 is essential for its helicase activity

COVID-19, caused by SARS-CoV-2, has been spreading worldwide for more than two years and has led to immense challenges to human health. Despite the great efforts that have been made, our understanding of SARS-CoV-2 is still limited. The viral helicase, NSP13 is an important enzyme involved in SARS-C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yue, Kun, Yao, Bin, Shi, Yingchao, Yang, Yang, Qian, Zhaohui, Ci, Yali, Shi, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864812/ https://www.ncbi.nlm.nih.gov/pubmed/35245742 http://dx.doi.org/10.1016/j.bbrc.2022.02.068

Ejemplares similares

An immunoinformatics approach to study the epitopes of SARS-CoV-2 helicase, Nsp13
por: Kumar, Sushant, et al.
Publicado: (2023)

Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro
por: Lu, Lian, et al.
Publicado: (2022)

Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase
por: White, Mark Andrew, et al.
Publicado: (2020)

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
por: Newman, Joseph A., et al.
Publicado: (2021)

Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase
por: Mickolajczyk, Keith J., et al.
Publicado: (2021)

Force-Dependent Stimulation of RNA Unwinding by SARS-CoV-2 NSP13 Helicase
por: Mickolajczyk, Keith J., et al.
Publicado: (2021)

Molecular dynamics simulations of the flexibility and inhibition of SARS-CoV-2 NSP 13 helicase
por: Raubenolt, Bryan A., et al.
Publicado: (2022)

In Silico Insights towards the Identification of SARS-CoV-2 NSP13 Helicase Druggable Pockets
por: Ricci, Federico, et al.
Publicado: (2022)

In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors
por: Gurung, Arun Bahadur
Publicado: (2020)

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
por: Zeng, Jingkun, et al.
Publicado: (2021)

In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity
por: Mohammad, Thahani S. Habeeb, et al.
Publicado: (2023)

ATPase and helicase activities of porcine epidemic diarrhea virus nsp13
por: Ren, Jie, et al.
Publicado: (2021)

Cooperative Activity of SARS Coronavirus Nsp13 Helicase Characterized by Single Molecule FRET
por: Im, Hyeryeon, et al.
Publicado: (2015)

Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13)
por: Ugurel, Osman Mutluhan, et al.
Publicado: (2020)

Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13
por: Lee, Na-Ra, et al.
Publicado: (2010)

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13
por: Yu, Mi-Sun, et al.
Publicado: (2012)

SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts
por: Shu, Ting, et al.
Publicado: (2020)

Potential phytochemical inhibitors of SARS-CoV-2 helicase Nsp13: a molecular docking and dynamic simulation study
por: Vivek-Ananth, R. P., et al.
Publicado: (2021)

Toward wide-spectrum antivirals against coronaviruses: Molecular characterization of SARS-CoV-2 NSP13 helicase inhibitors
por: Perez-Lemus, Gustavo R., et al.
Publicado: (2022)

SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1
por: Fung, Sin-Yee, et al.
Publicado: (2022)

Unwinding mechanism of SARS-CoV helicase (nsp13) in the presence of Ca(2+), elucidated by biochemical and single-molecular studies
por: Yu, Jeongmin, et al.
Publicado: (2023)

Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology?
por: Herbert, Alan, et al.
Publicado: (2022)

Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase
por: Mirza, Muhammad Usman, et al.
Publicado: (2020)

Biochemical analysis of SARS-CoV-2 Nsp13 helicase implicated in COVID-19 and factors that regulate its catalytic functions
por: Sommers, Joshua A., et al.
Publicado: (2023)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA
por: Jang, Kyoung-Jin, et al.
Publicado: (2020)

Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors
por: El Hassab, Mahmoud A., et al.
Publicado: (2022)

Molecular cloning, expression, and purification of SARS-CoV nsp13
por: Fan, Zheng, et al.
Publicado: (2005)

SARS-CoV-2 helicase NSP13 hijacks the host protein EWSR1 to promote viral replication by enhancing RNA unwinding activity
por: Zeng, Hongxiang, et al.
Publicado: (2022)

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance
por: Grimes, Samantha L., et al.
Publicado: (2023)

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
por: Kozielski, Frank, et al.
Publicado: (2021)

An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cells
por: Fang, Shouguo, et al.
Publicado: (2007)

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity
por: Lin, Sheng, et al.
Publicado: (2021)

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms
por: Vazquez, Christine, et al.
Publicado: (2021)

Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach
por: Romeo, Isabella, et al.
Publicado: (2022)

Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations
por: Vardhan, Seshu, et al.
Publicado: (2021)

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Abstract 2676: SARS-CoV-2 Nsp13 Catalytic Efficiency is Regulated by ATP: Mg2+ Stoichiometry and Functional Cooperativity Among Nsp13 Molecules
por: Haren, Caitlin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6b77mm1bfdm18vga3p2pokllvp