METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N(6)-methyladenosine modification of PD-L1 mRNA in breast cancer

BACKGROUND: Continual expression of PD-L1 in tumor cells is critical for tumor immune escape and host T cell exhaustion, however, knowledge on its clinical benefits through inhibition is limited in breast cancer. N(6)-methyladenosine (m(6)A) plays a crucial role in multiple biological activities. Ou...

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Detalles Bibliográficos
Autores principales: Wan, Weijun, Ao, Xiang, Chen, Quan, Yu, Yang, Ao, Luoquan, Xing, Wei, Guo, Wei, Wu, Xiaofeng, Pu, Chengxiu, Hu, Xueting, Li, Zhan, Yao, Mengwei, Luo, Donglin, Xu, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864846/
https://www.ncbi.nlm.nih.gov/pubmed/35197058
http://dx.doi.org/10.1186/s12943-021-01447-y

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