Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?

COVID-19 infection was mainly associated with respiratory symptoms, but lately, ischemic stroke (IS) has been reported in several cases. The incidence of IS in SARS-CoV-2 infection is increasing, and its mechanism is still not fully understood. Calcitonin gene-related peptide (CGRP) -the abundantly...

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Autores principales: Ouerdane, Yassamine, Khlidj, Yahia, Attia, Mohamed S., Korissi, Rafik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864889/
https://www.ncbi.nlm.nih.gov/pubmed/35228771
http://dx.doi.org/10.1016/j.mehy.2022.110807
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author Ouerdane, Yassamine
Khlidj, Yahia
Attia, Mohamed S.
Korissi, Rafik
author_facet Ouerdane, Yassamine
Khlidj, Yahia
Attia, Mohamed S.
Korissi, Rafik
author_sort Ouerdane, Yassamine
collection PubMed
description COVID-19 infection was mainly associated with respiratory symptoms, but lately, ischemic stroke (IS) has been reported in several cases. The incidence of IS in SARS-CoV-2 infection is increasing, and its mechanism is still not fully understood. Calcitonin gene-related peptide (CGRP) -the abundantly expressed protein in the peripheral and central nervous system- showed low expression in SARS-CoV-2 patients. This peptide is strongly implicated in regulating cerebral blood flow (CBF) and improving neurological deficits after cerebral arterial occlusion. We assume that a possible interplay between the low circulating levels of CGRP may affect CBF, thus worsening the symptoms of IS in SARS-CoV-2 patients.
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spelling pubmed-88648892022-02-24 Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection? Ouerdane, Yassamine Khlidj, Yahia Attia, Mohamed S. Korissi, Rafik Med Hypotheses Correspondence COVID-19 infection was mainly associated with respiratory symptoms, but lately, ischemic stroke (IS) has been reported in several cases. The incidence of IS in SARS-CoV-2 infection is increasing, and its mechanism is still not fully understood. Calcitonin gene-related peptide (CGRP) -the abundantly expressed protein in the peripheral and central nervous system- showed low expression in SARS-CoV-2 patients. This peptide is strongly implicated in regulating cerebral blood flow (CBF) and improving neurological deficits after cerebral arterial occlusion. We assume that a possible interplay between the low circulating levels of CGRP may affect CBF, thus worsening the symptoms of IS in SARS-CoV-2 patients. Elsevier Ltd. 2022-05 2022-02-23 /pmc/articles/PMC8864889/ /pubmed/35228771 http://dx.doi.org/10.1016/j.mehy.2022.110807 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Correspondence
Ouerdane, Yassamine
Khlidj, Yahia
Attia, Mohamed S.
Korissi, Rafik
Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?
title Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?
title_full Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?
title_fullStr Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?
title_full_unstemmed Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?
title_short Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?
title_sort calcitonin gene-related peptide: a biomarker for stroke in sars-cov-2 infection?
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864889/
https://www.ncbi.nlm.nih.gov/pubmed/35228771
http://dx.doi.org/10.1016/j.mehy.2022.110807
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