Absence, loss-of-function, or inhibition of Escherichia coli AcrB does not increase expression of other efflux pump genes supporting the discovery of AcrB inhibitors as antibiotic adjuvants

OBJECTIVES: To determine whether expression of efflux pumps and antibiotic susceptibility are altered in Escherichia coli in response to efflux inhibition. METHODS: The promoter regions of nine efflux pump genes (acrAB, acrD, acrEF, emrAB, macAB, cusCFBA, mdtK, mdtABC, mdfA) were fused to gfp in pMW...

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Detalles Bibliográficos
Autores principales: Ciusa, Maria Laura, Marshall, Robert L, Ricci, Vito, Stone, Jack W, Piddock, Laura J V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865010/
https://www.ncbi.nlm.nih.gov/pubmed/34897478
http://dx.doi.org/10.1093/jac/dkab452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865010/
https://www.ncbi.nlm.nih.gov/pubmed/34897478
http://dx.doi.org/10.1093/jac/dkab452

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