Molecular basis for the evolved instability of a human G-protein coupled receptor

Membrane proteins are prone to misfolding and degradation. This is particularly true for mammalian forms of the gonadotropin-releasing hormone receptor (GnRHR). Although they function at the plasma membrane, mammalian GnRHRs accumulate within the secretory pathway. Their apparent instability is beli...

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Detalles Bibliográficos
Autores principales: Chamness, Laura M., Zelt, Nathan B., Harrington, Haley R., Kuntz, Charles P., Bender, Brian J., Penn, Wesley D., Ziarek, Joshua J., Meiler, Jens, Schlebach, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865034/
https://www.ncbi.nlm.nih.gov/pubmed/34818554
http://dx.doi.org/10.1016/j.celrep.2021.110046

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