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Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients
OBJECTIVE: The haptoglobin (Hp) gene located on chromosome 16q22 exhibits a polymorphism that can impact its capacity to inhibit the deleterious oxidative activity of free hemoglobin. We aimed to determine the influence of Hp polymorphism on oxidative stress, lipid profile, and cardiovascular risk i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865067/ https://www.ncbi.nlm.nih.gov/pubmed/35229039 http://dx.doi.org/10.1002/hsr2.465 |
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author | Kengne Fotsing, Christian Bernard Pieme, Constant Anatole Biapa Nya, Prosper Cabral Chedjou, Jean Paul Dabou, Solange Nguemeni, Carine Teto, Georges Mbacham, Wilfred Fon Gatsing, Donatien |
author_facet | Kengne Fotsing, Christian Bernard Pieme, Constant Anatole Biapa Nya, Prosper Cabral Chedjou, Jean Paul Dabou, Solange Nguemeni, Carine Teto, Georges Mbacham, Wilfred Fon Gatsing, Donatien |
author_sort | Kengne Fotsing, Christian Bernard |
collection | PubMed |
description | OBJECTIVE: The haptoglobin (Hp) gene located on chromosome 16q22 exhibits a polymorphism that can impact its capacity to inhibit the deleterious oxidative activity of free hemoglobin. We aimed to determine the influence of Hp polymorphism on oxidative stress, lipid profile, and cardiovascular risk in Cameroonian sickle cell anemia patients (SCA patients). METHOD: The Hp genotypes of 102 SCA patients (SS), 60 healthy individuals (AA), and 55 subjects with sickle cell trait (AS) were determined by allele‐specific PCR, and the blood parameters were assessed using standard methods. RESULTS: Hp2‐2 genotype was significantly (P < .05) present in SS (54%) than in AS (42%) and AA (38%). Levels of catalase and cell reactive protein were higher, while levels of total antioxidant capacity, triglycerides, low‐density lipoprotein cholestetol, blood pressure, Framingham score, and body mass index were lower in the SCA patients. These parameters appeared to be unrelated to the haptoglobin genotypes. SCA patients with Hp1‐1 genotype presented a higher oxidative stress index (0.53 ± 0.31) than those with Hp2‐1 (0.33 ± 0.18). Lipid profile and cardiovascular risk were not significantly different between various Hp genotypes in SCA patients. CONCLUSION: Haptoglobin polymorphism did not affect lipid profile, cardiovascular risk, and oxidative stress status of SCA patients. Nevertheless, SCA patients with Hp1‐1 genotype tended to be more prone to oxidative stress than those with Hp2‐1. |
format | Online Article Text |
id | pubmed-8865067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88650672022-02-27 Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients Kengne Fotsing, Christian Bernard Pieme, Constant Anatole Biapa Nya, Prosper Cabral Chedjou, Jean Paul Dabou, Solange Nguemeni, Carine Teto, Georges Mbacham, Wilfred Fon Gatsing, Donatien Health Sci Rep Research Articles OBJECTIVE: The haptoglobin (Hp) gene located on chromosome 16q22 exhibits a polymorphism that can impact its capacity to inhibit the deleterious oxidative activity of free hemoglobin. We aimed to determine the influence of Hp polymorphism on oxidative stress, lipid profile, and cardiovascular risk in Cameroonian sickle cell anemia patients (SCA patients). METHOD: The Hp genotypes of 102 SCA patients (SS), 60 healthy individuals (AA), and 55 subjects with sickle cell trait (AS) were determined by allele‐specific PCR, and the blood parameters were assessed using standard methods. RESULTS: Hp2‐2 genotype was significantly (P < .05) present in SS (54%) than in AS (42%) and AA (38%). Levels of catalase and cell reactive protein were higher, while levels of total antioxidant capacity, triglycerides, low‐density lipoprotein cholestetol, blood pressure, Framingham score, and body mass index were lower in the SCA patients. These parameters appeared to be unrelated to the haptoglobin genotypes. SCA patients with Hp1‐1 genotype presented a higher oxidative stress index (0.53 ± 0.31) than those with Hp2‐1 (0.33 ± 0.18). Lipid profile and cardiovascular risk were not significantly different between various Hp genotypes in SCA patients. CONCLUSION: Haptoglobin polymorphism did not affect lipid profile, cardiovascular risk, and oxidative stress status of SCA patients. Nevertheless, SCA patients with Hp1‐1 genotype tended to be more prone to oxidative stress than those with Hp2‐1. John Wiley and Sons Inc. 2022-01-21 /pmc/articles/PMC8865067/ /pubmed/35229039 http://dx.doi.org/10.1002/hsr2.465 Text en © 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Kengne Fotsing, Christian Bernard Pieme, Constant Anatole Biapa Nya, Prosper Cabral Chedjou, Jean Paul Dabou, Solange Nguemeni, Carine Teto, Georges Mbacham, Wilfred Fon Gatsing, Donatien Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients |
title | Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients |
title_full | Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients |
title_fullStr | Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients |
title_full_unstemmed | Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients |
title_short | Relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients |
title_sort | relation between haptoglobin polymorphism and oxidative stress status, lipid profile, and cardiovascular risk in sickle cell anemia patients |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865067/ https://www.ncbi.nlm.nih.gov/pubmed/35229039 http://dx.doi.org/10.1002/hsr2.465 |
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