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Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations

Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we...

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Autores principales: Zhou, Shenping, Ding, Rongrong, Zhuang, Zhanwei, Zeng, Haiyu, Wen, Shuxian, Ruan, Donglin, Wu, Jie, Qiu, Yibin, Zheng, Enqin, Cai, Gengyuan, Yang, Jie, Wu, Zhenfang, Yang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865076/
https://www.ncbi.nlm.nih.gov/pubmed/35224076
http://dx.doi.org/10.3389/fvets.2021.807003
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author Zhou, Shenping
Ding, Rongrong
Zhuang, Zhanwei
Zeng, Haiyu
Wen, Shuxian
Ruan, Donglin
Wu, Jie
Qiu, Yibin
Zheng, Enqin
Cai, Gengyuan
Yang, Jie
Wu, Zhenfang
Yang, Ming
author_facet Zhou, Shenping
Ding, Rongrong
Zhuang, Zhanwei
Zeng, Haiyu
Wen, Shuxian
Ruan, Donglin
Wu, Jie
Qiu, Yibin
Zheng, Enqin
Cai, Gengyuan
Yang, Jie
Wu, Zhenfang
Yang, Ming
author_sort Zhou, Shenping
collection PubMed
description Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we performed single-trait and multi-trait genome-wide association studies (GWASs) for CC, AC, and WC in 2,206 American origin Duroc (AOD) and 2,082 Canadian origin Duroc (COD) pigs. As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) one was associated with CC and AC in COD pigs, which spans 6.92 Mb (from 170.06 to 176.98 Mb). Moreover, multi-trait GWAS identified 21 significant SNPs associated with the three conformation traits, indicating the multi-trait GWAS is a powerful statistical approach that uncovers pleiotropic locus. Finally, the three candidate genes (ITGA11, TLE3, and GALC) were selected that may play a role in the conformation traits. Further bioinformatics analysis indicated that the candidate genes for the three conformation traits mainly participated in sphingolipid metabolism and lysosome pathways. For all we know, this study was the first GWAS for WC in pigs. In general, our findings further reveal the genetic architecture of CC, AC, and WC, which may offer a useful reference for improving the conformation traits in pigs.
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spelling pubmed-88650762022-02-24 Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations Zhou, Shenping Ding, Rongrong Zhuang, Zhanwei Zeng, Haiyu Wen, Shuxian Ruan, Donglin Wu, Jie Qiu, Yibin Zheng, Enqin Cai, Gengyuan Yang, Jie Wu, Zhenfang Yang, Ming Front Vet Sci Veterinary Science Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we performed single-trait and multi-trait genome-wide association studies (GWASs) for CC, AC, and WC in 2,206 American origin Duroc (AOD) and 2,082 Canadian origin Duroc (COD) pigs. As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) one was associated with CC and AC in COD pigs, which spans 6.92 Mb (from 170.06 to 176.98 Mb). Moreover, multi-trait GWAS identified 21 significant SNPs associated with the three conformation traits, indicating the multi-trait GWAS is a powerful statistical approach that uncovers pleiotropic locus. Finally, the three candidate genes (ITGA11, TLE3, and GALC) were selected that may play a role in the conformation traits. Further bioinformatics analysis indicated that the candidate genes for the three conformation traits mainly participated in sphingolipid metabolism and lysosome pathways. For all we know, this study was the first GWAS for WC in pigs. In general, our findings further reveal the genetic architecture of CC, AC, and WC, which may offer a useful reference for improving the conformation traits in pigs. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8865076/ /pubmed/35224076 http://dx.doi.org/10.3389/fvets.2021.807003 Text en Copyright © 2022 Zhou, Ding, Zhuang, Zeng, Wen, Ruan, Wu, Qiu, Zheng, Cai, Yang, Wu and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Zhou, Shenping
Ding, Rongrong
Zhuang, Zhanwei
Zeng, Haiyu
Wen, Shuxian
Ruan, Donglin
Wu, Jie
Qiu, Yibin
Zheng, Enqin
Cai, Gengyuan
Yang, Jie
Wu, Zhenfang
Yang, Ming
Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations
title Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations
title_full Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations
title_fullStr Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations
title_full_unstemmed Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations
title_short Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations
title_sort genome-wide association analysis reveals genetic loci and candidate genes for chest, abdominal, and waist circumferences in two duroc pig populations
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865076/
https://www.ncbi.nlm.nih.gov/pubmed/35224076
http://dx.doi.org/10.3389/fvets.2021.807003
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