Cargando…
Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations
Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865076/ https://www.ncbi.nlm.nih.gov/pubmed/35224076 http://dx.doi.org/10.3389/fvets.2021.807003 |
_version_ | 1784655577340706816 |
---|---|
author | Zhou, Shenping Ding, Rongrong Zhuang, Zhanwei Zeng, Haiyu Wen, Shuxian Ruan, Donglin Wu, Jie Qiu, Yibin Zheng, Enqin Cai, Gengyuan Yang, Jie Wu, Zhenfang Yang, Ming |
author_facet | Zhou, Shenping Ding, Rongrong Zhuang, Zhanwei Zeng, Haiyu Wen, Shuxian Ruan, Donglin Wu, Jie Qiu, Yibin Zheng, Enqin Cai, Gengyuan Yang, Jie Wu, Zhenfang Yang, Ming |
author_sort | Zhou, Shenping |
collection | PubMed |
description | Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we performed single-trait and multi-trait genome-wide association studies (GWASs) for CC, AC, and WC in 2,206 American origin Duroc (AOD) and 2,082 Canadian origin Duroc (COD) pigs. As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) one was associated with CC and AC in COD pigs, which spans 6.92 Mb (from 170.06 to 176.98 Mb). Moreover, multi-trait GWAS identified 21 significant SNPs associated with the three conformation traits, indicating the multi-trait GWAS is a powerful statistical approach that uncovers pleiotropic locus. Finally, the three candidate genes (ITGA11, TLE3, and GALC) were selected that may play a role in the conformation traits. Further bioinformatics analysis indicated that the candidate genes for the three conformation traits mainly participated in sphingolipid metabolism and lysosome pathways. For all we know, this study was the first GWAS for WC in pigs. In general, our findings further reveal the genetic architecture of CC, AC, and WC, which may offer a useful reference for improving the conformation traits in pigs. |
format | Online Article Text |
id | pubmed-8865076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88650762022-02-24 Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations Zhou, Shenping Ding, Rongrong Zhuang, Zhanwei Zeng, Haiyu Wen, Shuxian Ruan, Donglin Wu, Jie Qiu, Yibin Zheng, Enqin Cai, Gengyuan Yang, Jie Wu, Zhenfang Yang, Ming Front Vet Sci Veterinary Science Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we performed single-trait and multi-trait genome-wide association studies (GWASs) for CC, AC, and WC in 2,206 American origin Duroc (AOD) and 2,082 Canadian origin Duroc (COD) pigs. As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) one was associated with CC and AC in COD pigs, which spans 6.92 Mb (from 170.06 to 176.98 Mb). Moreover, multi-trait GWAS identified 21 significant SNPs associated with the three conformation traits, indicating the multi-trait GWAS is a powerful statistical approach that uncovers pleiotropic locus. Finally, the three candidate genes (ITGA11, TLE3, and GALC) were selected that may play a role in the conformation traits. Further bioinformatics analysis indicated that the candidate genes for the three conformation traits mainly participated in sphingolipid metabolism and lysosome pathways. For all we know, this study was the first GWAS for WC in pigs. In general, our findings further reveal the genetic architecture of CC, AC, and WC, which may offer a useful reference for improving the conformation traits in pigs. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8865076/ /pubmed/35224076 http://dx.doi.org/10.3389/fvets.2021.807003 Text en Copyright © 2022 Zhou, Ding, Zhuang, Zeng, Wen, Ruan, Wu, Qiu, Zheng, Cai, Yang, Wu and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Zhou, Shenping Ding, Rongrong Zhuang, Zhanwei Zeng, Haiyu Wen, Shuxian Ruan, Donglin Wu, Jie Qiu, Yibin Zheng, Enqin Cai, Gengyuan Yang, Jie Wu, Zhenfang Yang, Ming Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations |
title | Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations |
title_full | Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations |
title_fullStr | Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations |
title_full_unstemmed | Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations |
title_short | Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations |
title_sort | genome-wide association analysis reveals genetic loci and candidate genes for chest, abdominal, and waist circumferences in two duroc pig populations |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865076/ https://www.ncbi.nlm.nih.gov/pubmed/35224076 http://dx.doi.org/10.3389/fvets.2021.807003 |
work_keys_str_mv | AT zhoushenping genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT dingrongrong genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT zhuangzhanwei genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT zenghaiyu genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT wenshuxian genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT ruandonglin genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT wujie genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT qiuyibin genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT zhengenqin genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT caigengyuan genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT yangjie genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT wuzhenfang genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations AT yangming genomewideassociationanalysisrevealsgeneticlociandcandidategenesforchestabdominalandwaistcircumferencesintwodurocpigpopulations |