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Delayed gastric emptying in nondiabetic patients with end-stage kidney disease

OBJECTIVE: This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. METHODS: Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled. All ESKD patients underwent ultrasound examinatio...

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Autores principales: Wang, Cuiyu, Chen, Chao, Wang, Jin, Guo, Xiaohua, Deng, Yuechan. C., Liu, Li, Zhao, Chunmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865106/
https://www.ncbi.nlm.nih.gov/pubmed/35188060
http://dx.doi.org/10.1080/0886022X.2022.2030754
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author Wang, Cuiyu
Chen, Chao
Wang, Jin
Guo, Xiaohua
Deng, Yuechan. C.
Liu, Li
Zhao, Chunmei
author_facet Wang, Cuiyu
Chen, Chao
Wang, Jin
Guo, Xiaohua
Deng, Yuechan. C.
Liu, Li
Zhao, Chunmei
author_sort Wang, Cuiyu
collection PubMed
description OBJECTIVE: This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. METHODS: Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled. All ESKD patients underwent ultrasound examinations on the day of hemodialysis (dialysis day) and the day after hemodialysis (nondialysis day). Standard ultrasound examinations were performed after overnight fasting, immediately after a light meal, and at 6 h after a meal. The antral cross-sectional area and gastric emptying according to the Perlas grading system were evaluated. RESULTS: Compared with the controls, patients with ESKD, on both dialysis and non-dialysis days, had significantly larger antral areas when examined in the supine position (p = 0.002 and p = 0.003, respectively), but not in the right lateral decubitus position (p = 0.452 and p = 0.512, respectively). In the supine position, the antral area of ESKD patients before dialysis (8 a.m. on the dialysis day) was larger than that at the same time on the nondialysis day (p = 0.028). The controls had a Perlas grade of either 0 or 1 at 6 h after a meal, whereas five patients (13.5%) and 11 patients (29.7%) in the ESKD group had Perlas grade 2 on the dialysis and non-dialysis days, respectively. Among patients with or without delayed gastric emptying, no differences were detected in the dialysis duration or levels of biochemical markers, except blood urea nitrogen (p = 0.038) and serum creatinine (p = 0.003). CONCLUSION: Nondiabetic patients with ESKD had significantly delayed gastric emptying. Hemodialysis might improve gastric emptying and reduce gastric emptying delay.
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spelling pubmed-88651062022-02-24 Delayed gastric emptying in nondiabetic patients with end-stage kidney disease Wang, Cuiyu Chen, Chao Wang, Jin Guo, Xiaohua Deng, Yuechan. C. Liu, Li Zhao, Chunmei Ren Fail Clinical Study OBJECTIVE: This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. METHODS: Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled. All ESKD patients underwent ultrasound examinations on the day of hemodialysis (dialysis day) and the day after hemodialysis (nondialysis day). Standard ultrasound examinations were performed after overnight fasting, immediately after a light meal, and at 6 h after a meal. The antral cross-sectional area and gastric emptying according to the Perlas grading system were evaluated. RESULTS: Compared with the controls, patients with ESKD, on both dialysis and non-dialysis days, had significantly larger antral areas when examined in the supine position (p = 0.002 and p = 0.003, respectively), but not in the right lateral decubitus position (p = 0.452 and p = 0.512, respectively). In the supine position, the antral area of ESKD patients before dialysis (8 a.m. on the dialysis day) was larger than that at the same time on the nondialysis day (p = 0.028). The controls had a Perlas grade of either 0 or 1 at 6 h after a meal, whereas five patients (13.5%) and 11 patients (29.7%) in the ESKD group had Perlas grade 2 on the dialysis and non-dialysis days, respectively. Among patients with or without delayed gastric emptying, no differences were detected in the dialysis duration or levels of biochemical markers, except blood urea nitrogen (p = 0.038) and serum creatinine (p = 0.003). CONCLUSION: Nondiabetic patients with ESKD had significantly delayed gastric emptying. Hemodialysis might improve gastric emptying and reduce gastric emptying delay. Taylor & Francis 2022-02-21 /pmc/articles/PMC8865106/ /pubmed/35188060 http://dx.doi.org/10.1080/0886022X.2022.2030754 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Wang, Cuiyu
Chen, Chao
Wang, Jin
Guo, Xiaohua
Deng, Yuechan. C.
Liu, Li
Zhao, Chunmei
Delayed gastric emptying in nondiabetic patients with end-stage kidney disease
title Delayed gastric emptying in nondiabetic patients with end-stage kidney disease
title_full Delayed gastric emptying in nondiabetic patients with end-stage kidney disease
title_fullStr Delayed gastric emptying in nondiabetic patients with end-stage kidney disease
title_full_unstemmed Delayed gastric emptying in nondiabetic patients with end-stage kidney disease
title_short Delayed gastric emptying in nondiabetic patients with end-stage kidney disease
title_sort delayed gastric emptying in nondiabetic patients with end-stage kidney disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865106/
https://www.ncbi.nlm.nih.gov/pubmed/35188060
http://dx.doi.org/10.1080/0886022X.2022.2030754
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