Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification

Germline or somatic variation in the family of KMT2 lysine methyltransferases have been associated with a variety of congenital disorders and cancers. Notably, KMT2A-fusions are prevalent in 70% of infant leukaemias but fail to phenocopy short latency leukaemogenesis in mammalian models, suggesting...

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Detalles Bibliográficos
Autores principales: Maurya, Shailendra, Yang, Wei, Tamai, Minori, Zhang, Qiang, Erdmann-Gilmore, Petra, Bystry, Amelia, Martins Rodrigues, Fernanda, Valentine, Mark C., Wong, Wing H, Townsend, Reid, Druley, Todd E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865227/
https://www.ncbi.nlm.nih.gov/pubmed/34304711
http://dx.doi.org/10.1080/15592294.2021.1954780

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