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Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia
BACKGROUND: It is well known that body temperature maintenance between 20 and 35°C prevents hypoxic damage. However, data regarding the ideal duration and permissible temperature boundaries for ultra-deep hypothermia below 20°C are rather fragmentary. The aim of the present study was to determine th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865344/ https://www.ncbi.nlm.nih.gov/pubmed/35075019 http://dx.doi.org/10.4103/aca.ACA_189_20 |
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author | Gagarinskiy, Evgeniy L Averin, Aleksey S Uteshev, Viktor K Sherbakov, Pavel V Telpuhov, Vladimir I Shvirst, Nikolay E Karpova, Yulya A Gurin, Artem E Varlachev, Aleksandr V Kovtun, Anatoliy L Fesenko, Eugeny E |
author_facet | Gagarinskiy, Evgeniy L Averin, Aleksey S Uteshev, Viktor K Sherbakov, Pavel V Telpuhov, Vladimir I Shvirst, Nikolay E Karpova, Yulya A Gurin, Artem E Varlachev, Aleksandr V Kovtun, Anatoliy L Fesenko, Eugeny E |
author_sort | Gagarinskiy, Evgeniy L |
collection | PubMed |
description | BACKGROUND: It is well known that body temperature maintenance between 20 and 35°C prevents hypoxic damage. However, data regarding the ideal duration and permissible temperature boundaries for ultra-deep hypothermia below 20°C are rather fragmentary. The aim of the present study was to determine the time limits of reversible clinical death in rats subjected to ultra-deep hypothermia at 1–8°C. RESULTS: Rat survival rates were directly dependent on the duration of clinical death. If clinical death did not exceed 35 min, animal viability could be restored. Extending the duration of clinical death longer than 45 min led to rat death, and cardiac functioning in these animals was not recovered. The rewarming rate and the lowest temperature of hypothermia experienced did not directly influence survival rates. CONCLUSIONS: In a rat model, reversible ultra-deep hypothermia as low as 1–8°C could be achieved without the application of hypercapnia or pharmacological support. The survival of animals was dependent on the duration of clinical death, which should not exceed 35 min. |
format | Online Article Text |
id | pubmed-8865344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-88653442022-03-10 Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia Gagarinskiy, Evgeniy L Averin, Aleksey S Uteshev, Viktor K Sherbakov, Pavel V Telpuhov, Vladimir I Shvirst, Nikolay E Karpova, Yulya A Gurin, Artem E Varlachev, Aleksandr V Kovtun, Anatoliy L Fesenko, Eugeny E Ann Card Anaesth Original Article BACKGROUND: It is well known that body temperature maintenance between 20 and 35°C prevents hypoxic damage. However, data regarding the ideal duration and permissible temperature boundaries for ultra-deep hypothermia below 20°C are rather fragmentary. The aim of the present study was to determine the time limits of reversible clinical death in rats subjected to ultra-deep hypothermia at 1–8°C. RESULTS: Rat survival rates were directly dependent on the duration of clinical death. If clinical death did not exceed 35 min, animal viability could be restored. Extending the duration of clinical death longer than 45 min led to rat death, and cardiac functioning in these animals was not recovered. The rewarming rate and the lowest temperature of hypothermia experienced did not directly influence survival rates. CONCLUSIONS: In a rat model, reversible ultra-deep hypothermia as low as 1–8°C could be achieved without the application of hypercapnia or pharmacological support. The survival of animals was dependent on the duration of clinical death, which should not exceed 35 min. Wolters Kluwer - Medknow 2022 2022-01-21 /pmc/articles/PMC8865344/ /pubmed/35075019 http://dx.doi.org/10.4103/aca.ACA_189_20 Text en Copyright: © 2022 Annals of Cardiac Anaesthesia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Gagarinskiy, Evgeniy L Averin, Aleksey S Uteshev, Viktor K Sherbakov, Pavel V Telpuhov, Vladimir I Shvirst, Nikolay E Karpova, Yulya A Gurin, Artem E Varlachev, Aleksandr V Kovtun, Anatoliy L Fesenko, Eugeny E Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia |
title | Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia |
title_full | Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia |
title_fullStr | Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia |
title_full_unstemmed | Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia |
title_short | Time Limiting Boundaries of Reversible Clinical Death in Rats Subjected to Ultra-Deep Hypothermia |
title_sort | time limiting boundaries of reversible clinical death in rats subjected to ultra-deep hypothermia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865344/ https://www.ncbi.nlm.nih.gov/pubmed/35075019 http://dx.doi.org/10.4103/aca.ACA_189_20 |
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