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Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study
INTRODUCTION: Various chronic pain conditions go along with functional and structural brain changes. This study aimed to investigate functional and structural brain changes by magnetic resonance imaging (MRI) in inflammatory bowel disease (IBD) patients with chronic abdominal pain. METHODS: Sixty-fo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865502/ https://www.ncbi.nlm.nih.gov/pubmed/35060939 http://dx.doi.org/10.14309/ctg.0000000000000453 |
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author | Prüß, Magdalena S. Bayer, Arian Bayer, Kian-Elias Schumann, Michael Atreya, Raja Mekle, Ralf Fiebach, Jochen B. Siegmund, Britta Neeb, Lars |
author_facet | Prüß, Magdalena S. Bayer, Arian Bayer, Kian-Elias Schumann, Michael Atreya, Raja Mekle, Ralf Fiebach, Jochen B. Siegmund, Britta Neeb, Lars |
author_sort | Prüß, Magdalena S. |
collection | PubMed |
description | INTRODUCTION: Various chronic pain conditions go along with functional and structural brain changes. This study aimed to investigate functional and structural brain changes by magnetic resonance imaging (MRI) in inflammatory bowel disease (IBD) patients with chronic abdominal pain. METHODS: Sixty-four subjects were included in the final analysis (32 IBD patients with chronic abdominal pain; 32 age-matched and sex-matched controls). All patients suffered from chronic abdominal pain, defined as a score of ≥3/10 on the visual analog scale for at least 3 months in the past 6 months. Besides structural MRI, resting state functional MRI was used to compare functional connectivity of 10 networks between groups. RESULTS: Patients with IBD showed no structural brain alterations but a significantly increased resting state functional connectivity of the secondary somatosensory cortex within the salience network. DISCUSSION: Because the secondary somatosensory cortex saves sensory stimuli and compares novel information with latter experiences, these functions may be maladaptive in IBD patients with abdominal pain. |
format | Online Article Text |
id | pubmed-8865502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-88655022022-02-24 Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study Prüß, Magdalena S. Bayer, Arian Bayer, Kian-Elias Schumann, Michael Atreya, Raja Mekle, Ralf Fiebach, Jochen B. Siegmund, Britta Neeb, Lars Clin Transl Gastroenterol Article INTRODUCTION: Various chronic pain conditions go along with functional and structural brain changes. This study aimed to investigate functional and structural brain changes by magnetic resonance imaging (MRI) in inflammatory bowel disease (IBD) patients with chronic abdominal pain. METHODS: Sixty-four subjects were included in the final analysis (32 IBD patients with chronic abdominal pain; 32 age-matched and sex-matched controls). All patients suffered from chronic abdominal pain, defined as a score of ≥3/10 on the visual analog scale for at least 3 months in the past 6 months. Besides structural MRI, resting state functional MRI was used to compare functional connectivity of 10 networks between groups. RESULTS: Patients with IBD showed no structural brain alterations but a significantly increased resting state functional connectivity of the secondary somatosensory cortex within the salience network. DISCUSSION: Because the secondary somatosensory cortex saves sensory stimuli and compares novel information with latter experiences, these functions may be maladaptive in IBD patients with abdominal pain. Wolters Kluwer 2022-02-19 /pmc/articles/PMC8865502/ /pubmed/35060939 http://dx.doi.org/10.14309/ctg.0000000000000453 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Article Prüß, Magdalena S. Bayer, Arian Bayer, Kian-Elias Schumann, Michael Atreya, Raja Mekle, Ralf Fiebach, Jochen B. Siegmund, Britta Neeb, Lars Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study |
title | Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study |
title_full | Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study |
title_fullStr | Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study |
title_full_unstemmed | Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study |
title_short | Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study |
title_sort | functional brain changes due to chronic abdominal pain in inflammatory bowel disease: a case-control magnetic resonance imaging study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865502/ https://www.ncbi.nlm.nih.gov/pubmed/35060939 http://dx.doi.org/10.14309/ctg.0000000000000453 |
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