Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models

Bone abnormalities affect all individuals with Down syndrome (DS) and are linked to abnormal expression of DYRK1A, a gene found in three copies in people with DS and Ts65Dn DS model mice. Previous work in Ts65Dn male mice demonstrated that both genetic normalization of Dyrk1a and treatment with ~9 m...

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Detalles Bibliográficos
Autores principales: Jamal, Raza, LaCombe, Jonathan, Patel, Roshni, Blackwell, Matthew, Thomas, Jared R., Sloan, Kourtney, Wallace, Joseph M., Roper, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865638/
https://www.ncbi.nlm.nih.gov/pubmed/35196359
http://dx.doi.org/10.1371/journal.pone.0264254

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