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Dynamic assembly of the mRNA m(6)A methyltransferase complex is regulated by METTL3 phase separation
m(6)A methylation is the most abundant and reversible chemical modification on mRNA with approximately one-fourth of eukaryotic mRNAs harboring at least one m(6)A-modified base. The recruitment of the mRNA m(6)A methyltransferase writer complex to phase-separated nuclear speckles is likely to be cru...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865655/ https://www.ncbi.nlm.nih.gov/pubmed/35143475 http://dx.doi.org/10.1371/journal.pbio.3001535 |