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A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient
Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived conditio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865742/ https://www.ncbi.nlm.nih.gov/pubmed/35228919 http://dx.doi.org/10.7759/cureus.21558 |
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author | Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick |
author_facet | Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick |
author_sort | Grove, John |
collection | PubMed |
description | Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived condition is not well understood but is thought to be due to recurring genetic mutations. GCTs have been linked with Noonan syndrome. Here, we report the case of a 17-year-old caucasian male who presented with partial upper airway obstruction due to a GCT. This case promotes awareness among pathologists and clinicians for this condition in the workup of patients presenting with upper airway obstruction. |
format | Online Article Text |
id | pubmed-8865742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-88657422022-02-27 A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick Cureus Pediatrics Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived condition is not well understood but is thought to be due to recurring genetic mutations. GCTs have been linked with Noonan syndrome. Here, we report the case of a 17-year-old caucasian male who presented with partial upper airway obstruction due to a GCT. This case promotes awareness among pathologists and clinicians for this condition in the workup of patients presenting with upper airway obstruction. Cureus 2022-01-24 /pmc/articles/PMC8865742/ /pubmed/35228919 http://dx.doi.org/10.7759/cureus.21558 Text en Copyright © 2022, Grove et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pediatrics Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient |
title | A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient |
title_full | A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient |
title_fullStr | A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient |
title_full_unstemmed | A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient |
title_short | A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient |
title_sort | rare case of granular cell tumor in the right upper lung of an adolescent patient |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865742/ https://www.ncbi.nlm.nih.gov/pubmed/35228919 http://dx.doi.org/10.7759/cureus.21558 |
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