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A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient

Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived conditio...

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Autores principales: Grove, John, Meier, Casey, Youssef, Bahaaeldin, Costello, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865742/
https://www.ncbi.nlm.nih.gov/pubmed/35228919
http://dx.doi.org/10.7759/cureus.21558
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author Grove, John
Meier, Casey
Youssef, Bahaaeldin
Costello, Patrick
author_facet Grove, John
Meier, Casey
Youssef, Bahaaeldin
Costello, Patrick
author_sort Grove, John
collection PubMed
description Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived condition is not well understood but is thought to be due to recurring genetic mutations. GCTs have been linked with Noonan syndrome. Here, we report the case of a 17-year-old caucasian male who presented with partial upper airway obstruction due to a GCT. This case promotes awareness among pathologists and clinicians for this condition in the workup of patients presenting with upper airway obstruction.
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spelling pubmed-88657422022-02-27 A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick Cureus Pediatrics Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived condition is not well understood but is thought to be due to recurring genetic mutations. GCTs have been linked with Noonan syndrome. Here, we report the case of a 17-year-old caucasian male who presented with partial upper airway obstruction due to a GCT. This case promotes awareness among pathologists and clinicians for this condition in the workup of patients presenting with upper airway obstruction. Cureus 2022-01-24 /pmc/articles/PMC8865742/ /pubmed/35228919 http://dx.doi.org/10.7759/cureus.21558 Text en Copyright © 2022, Grove et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Grove, John
Meier, Casey
Youssef, Bahaaeldin
Costello, Patrick
A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient
title A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient
title_full A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient
title_fullStr A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient
title_full_unstemmed A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient
title_short A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient
title_sort rare case of granular cell tumor in the right upper lung of an adolescent patient
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865742/
https://www.ncbi.nlm.nih.gov/pubmed/35228919
http://dx.doi.org/10.7759/cureus.21558
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