Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG ‘hotspot’ mutation

The T618I KCNH2-encoded hERG mutation is the most frequently observed mutation in genotyped cases of the congenital short QT syndrome (SQTS), a cardiac condition associated with ventricular fibrillation and sudden death. Most T618I hERG carriers exhibit a pronounced U wave on the electrocardiogram a...

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Detalles Bibliográficos
Autores principales: Du, Chunyun, Zhang, Henggui, Harmer, Stephen C., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865743/
https://www.ncbi.nlm.nih.gov/pubmed/35114584
http://dx.doi.org/10.1016/j.bbrc.2022.01.057

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