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A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis

Primary cilia are sensory antennae crucial for cell and organism development, and defects in their biogenesis cause ciliopathies. Ciliogenesis involves membrane trafficking mediated by small guanosine triphosphatases (GTPases) including Rabs, molecular switches activated by guanine nucleotide exchan...

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Detalles Bibliográficos
Autores principales:	Kumar, Rahul, Francis, Vincent, Kulasekaran, Gopinath, Khan, Maleeha, Armstrong, Gary A. B., McPherson, Peter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865772/ https://www.ncbi.nlm.nih.gov/pubmed/35196081 http://dx.doi.org/10.1126/sciadv.abk3088

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