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Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation

Decidualization is an intricate biological process in which extensive remodeling of the endometrium occurs to support the development of an implanting blastocyst. However, the immunometabolic mechanisms underlying this process are still largely unknown. We found that the decidualization process is a...

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Autores principales: Zhou, Wen-Jie, Yang, Hui-Li, Mei, Jie, Chang, Kai-Kai, Lu, Han, Lai, Zhen-Zhen, Shi, Jia-Wei, Wang, Xiao-Hui, Wu, Ke, Zhang, Tao, Wang, Jian, Sun, Jian-Song, Ye, Jiang-Feng, Li, Da-Jin, Zhao, Jian-Yuan, Jin, Li-Ping, Li, Ming-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865779/
https://www.ncbi.nlm.nih.gov/pubmed/35196096
http://dx.doi.org/10.1126/sciadv.abj2488
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author Zhou, Wen-Jie
Yang, Hui-Li
Mei, Jie
Chang, Kai-Kai
Lu, Han
Lai, Zhen-Zhen
Shi, Jia-Wei
Wang, Xiao-Hui
Wu, Ke
Zhang, Tao
Wang, Jian
Sun, Jian-Song
Ye, Jiang-Feng
Li, Da-Jin
Zhao, Jian-Yuan
Jin, Li-Ping
Li, Ming-Qing
author_facet Zhou, Wen-Jie
Yang, Hui-Li
Mei, Jie
Chang, Kai-Kai
Lu, Han
Lai, Zhen-Zhen
Shi, Jia-Wei
Wang, Xiao-Hui
Wu, Ke
Zhang, Tao
Wang, Jian
Sun, Jian-Song
Ye, Jiang-Feng
Li, Da-Jin
Zhao, Jian-Yuan
Jin, Li-Ping
Li, Ming-Qing
author_sort Zhou, Wen-Jie
collection PubMed
description Decidualization is an intricate biological process in which extensive remodeling of the endometrium occurs to support the development of an implanting blastocyst. However, the immunometabolic mechanisms underlying this process are still largely unknown. We found that the decidualization process is accompanied by the accumulation of fructose-1,6-bisphosphate (FBP). The combination of FBP with pyruvate kinase M stimulated IL-27 secretion by endometrial stromal cells in an ERK/c-FOS–dependent manner. IL-27 induced decidual COX-2(+) M2-like macrophage differentiation, which promotes decidualization, trophoblast invasion, and maternal-fetal tolerance. Transfer of Ptgs2(+)/COX-2(+) macrophages prevented fetal loss in Il27ra-deleted pregnant mice. FBP levels were low in plasma and decidual tissues of patients with unexplained recurrent spontaneous abortion. In therapeutic studies, FBP supplementation significantly improved embryo loss by up-regulation of IL-27–induced COX-2(+) macrophage differentiation in a mouse model of spontaneous abortion. These findings collectively provide a scientific basis for a potential therapeutic strategy to prevent pregnancy loss.
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spelling pubmed-88657792022-03-10 Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation Zhou, Wen-Jie Yang, Hui-Li Mei, Jie Chang, Kai-Kai Lu, Han Lai, Zhen-Zhen Shi, Jia-Wei Wang, Xiao-Hui Wu, Ke Zhang, Tao Wang, Jian Sun, Jian-Song Ye, Jiang-Feng Li, Da-Jin Zhao, Jian-Yuan Jin, Li-Ping Li, Ming-Qing Sci Adv Biomedicine and Life Sciences Decidualization is an intricate biological process in which extensive remodeling of the endometrium occurs to support the development of an implanting blastocyst. However, the immunometabolic mechanisms underlying this process are still largely unknown. We found that the decidualization process is accompanied by the accumulation of fructose-1,6-bisphosphate (FBP). The combination of FBP with pyruvate kinase M stimulated IL-27 secretion by endometrial stromal cells in an ERK/c-FOS–dependent manner. IL-27 induced decidual COX-2(+) M2-like macrophage differentiation, which promotes decidualization, trophoblast invasion, and maternal-fetal tolerance. Transfer of Ptgs2(+)/COX-2(+) macrophages prevented fetal loss in Il27ra-deleted pregnant mice. FBP levels were low in plasma and decidual tissues of patients with unexplained recurrent spontaneous abortion. In therapeutic studies, FBP supplementation significantly improved embryo loss by up-regulation of IL-27–induced COX-2(+) macrophage differentiation in a mouse model of spontaneous abortion. These findings collectively provide a scientific basis for a potential therapeutic strategy to prevent pregnancy loss. American Association for the Advancement of Science 2022-02-23 /pmc/articles/PMC8865779/ /pubmed/35196096 http://dx.doi.org/10.1126/sciadv.abj2488 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Zhou, Wen-Jie
Yang, Hui-Li
Mei, Jie
Chang, Kai-Kai
Lu, Han
Lai, Zhen-Zhen
Shi, Jia-Wei
Wang, Xiao-Hui
Wu, Ke
Zhang, Tao
Wang, Jian
Sun, Jian-Song
Ye, Jiang-Feng
Li, Da-Jin
Zhao, Jian-Yuan
Jin, Li-Ping
Li, Ming-Qing
Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation
title Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation
title_full Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation
title_fullStr Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation
title_full_unstemmed Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation
title_short Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation
title_sort fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual cox-2(+) macrophage differentiation
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865779/
https://www.ncbi.nlm.nih.gov/pubmed/35196096
http://dx.doi.org/10.1126/sciadv.abj2488
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