Ribonucleotide reductase, a novel drug target for gonorrhea

Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum of activity against Ng including MDR isolates....

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Detalles Bibliográficos
Autores principales: Narasimhan, Jana, Letinski, Suzanne, Jung, Stephen P, Gerasyuto, Aleksey, Wang, Jiashi, Arnold, Michael, Chen, Guangming, Hedrick, Jean, Dumble, Melissa, Ravichandran, Kanchana, Levitz, Talya, Cui, Chang, Drennan, Catherine L, Stubbe, JoAnne, Karp, Gary, Branstrom, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865847/
https://www.ncbi.nlm.nih.gov/pubmed/35137690
http://dx.doi.org/10.7554/eLife.67447

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