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CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor

BACKGROUND: Following our 2015 elucidation of the CASP1/NALP3 inflammasome mechanism of glucocorticoid (GC)-resistance in pediatric acute lymphoblastic leukemia (ALL) patients, we engineered a cell-based CASP1/NALP3 reporter system suitable for high-throughput screening (HTS) of small molecule libra...

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Detalles Bibliográficos
Autores principales:	Zou, Chan, Beard, Jordan A, Yang, Guoping, Evans, William E, Bonten, Erik J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865862/ https://www.ncbi.nlm.nih.gov/pubmed/35221708 http://dx.doi.org/10.2147/JIR.S333725

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