Two Patient Studies of a Companion Diagnostic Immuno-Positron Emission Tomography (PET) Tracer for Measuring Human CA6 Expression in Cancer for Antibody Drug Conjugate (ADC) Therapy

An antigen binding fragment (BFab) derived from a tumor-associated mucin 1–sialoglycotope antigen (CA6) targeting antibody (huDS6) was engineered. We synthesized a companion diagnostic positron emission tomography (PET) tracer by radiolabeling BFab with [(64)Cu] to measure CA6 expression on cancer t...

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Detalles Bibliográficos
Autores principales: Natarajan, Arutselvan, Srinivas, Shyam M., Azevedo, Carmen, Greene, Lacey, Bauchet, Anne-Laure, Jouannot, Erwan, Lacoste-Bourgeacq, Anne-Sophie, Guizon, Isabelle, Cohen, Patrick, Naneix, Anne-Laure, Ilovich, Ohad, Cisneros, Jordan, Rupanarayan, Krithika, Chin, Frederick T., Iagaru, Andrei, Dirbas, Frederick M., Karam, Amer, Gambhir, Sanjiv S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865942/
https://www.ncbi.nlm.nih.gov/pubmed/33104454
http://dx.doi.org/10.1177/1536012120939398

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