Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling

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Surface-targeting biotherapeutic agents have been successful in treating HER2-amplified cancers through immunostimulation or chemodelivery but have failed to produce effective inhibitors of constitutive HER2-HER3 signaling. We report an extensive structure-function analysis of this tumor driver, rev...

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Detalles Bibliográficos
Autores principales: Campbell, Marcia R., Ruiz-Saenz, Ana, Zhang, Yuntian, Peterson, Elliott, Steri, Veronica, Oeffinger, Julie, Sampang, Maryjo, Jura, Natalia, Moasser, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865943/
https://www.ncbi.nlm.nih.gov/pubmed/35108526
http://dx.doi.org/10.1016/j.celrep.2021.110285
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