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Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome

The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate the MvRL-rich fraction from M. vacciniifolia rhizome for an...

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Autores principales: da Silva, Gabriela Cavalcante, de Oliveira, Alisson Macário, Costa, Wêndeo Kennedy, da Silva Filho, Antônio Felix, Pitta, Maira Galdino da Rocha, Rêgo, Moacyr Jesus Barreto de Melo, Antônia de Souza, Ivone, Paiva, Patrícia Maria Guedes, Napoleão, Thiago Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866057/
https://www.ncbi.nlm.nih.gov/pubmed/35243335
http://dx.doi.org/10.1016/j.crphar.2022.100093
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author da Silva, Gabriela Cavalcante
de Oliveira, Alisson Macário
Costa, Wêndeo Kennedy
da Silva Filho, Antônio Felix
Pitta, Maira Galdino da Rocha
Rêgo, Moacyr Jesus Barreto de Melo
Antônia de Souza, Ivone
Paiva, Patrícia Maria Guedes
Napoleão, Thiago Henrique
author_facet da Silva, Gabriela Cavalcante
de Oliveira, Alisson Macário
Costa, Wêndeo Kennedy
da Silva Filho, Antônio Felix
Pitta, Maira Galdino da Rocha
Rêgo, Moacyr Jesus Barreto de Melo
Antônia de Souza, Ivone
Paiva, Patrícia Maria Guedes
Napoleão, Thiago Henrique
author_sort da Silva, Gabriela Cavalcante
collection PubMed
description The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate the MvRL-rich fraction from M. vacciniifolia rhizome for antibacterial activity in vitro and in vivo as well as antitumor effect in vivo using the Ehrlich carcinoma model in mice. The fraction showed antibacterial activity against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus with minimal inhibitory concentrations ranging from 31.2 to 125.0 ​μg/mL and minimal bactericidal concentrations from 62.5 to 200 ​μg/mL. The fraction was also effective in vivo against infection caused by these bacteria on Tenebrio molitor larvae considering the parameters evaluated. In regard to the antitumor activity, the treatments of Ehrlich carcinoma-bearing mice with the fraction at 100 and 200 ​mg/kg per os resulted in 62.58% and 75.43% of tumor inhibition, respectively. In conclusion, the MvRL-rich fraction showed in vivo antibacterial and antitumor activities and thus can be considered as an alternative of natural origin for the development of candidates for therapy.
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spelling pubmed-88660572022-03-02 Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome da Silva, Gabriela Cavalcante de Oliveira, Alisson Macário Costa, Wêndeo Kennedy da Silva Filho, Antônio Felix Pitta, Maira Galdino da Rocha Rêgo, Moacyr Jesus Barreto de Melo Antônia de Souza, Ivone Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique Curr Res Pharmacol Drug Discov Research Article The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate the MvRL-rich fraction from M. vacciniifolia rhizome for antibacterial activity in vitro and in vivo as well as antitumor effect in vivo using the Ehrlich carcinoma model in mice. The fraction showed antibacterial activity against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus with minimal inhibitory concentrations ranging from 31.2 to 125.0 ​μg/mL and minimal bactericidal concentrations from 62.5 to 200 ​μg/mL. The fraction was also effective in vivo against infection caused by these bacteria on Tenebrio molitor larvae considering the parameters evaluated. In regard to the antitumor activity, the treatments of Ehrlich carcinoma-bearing mice with the fraction at 100 and 200 ​mg/kg per os resulted in 62.58% and 75.43% of tumor inhibition, respectively. In conclusion, the MvRL-rich fraction showed in vivo antibacterial and antitumor activities and thus can be considered as an alternative of natural origin for the development of candidates for therapy. Elsevier 2022-02-17 /pmc/articles/PMC8866057/ /pubmed/35243335 http://dx.doi.org/10.1016/j.crphar.2022.100093 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
da Silva, Gabriela Cavalcante
de Oliveira, Alisson Macário
Costa, Wêndeo Kennedy
da Silva Filho, Antônio Felix
Pitta, Maira Galdino da Rocha
Rêgo, Moacyr Jesus Barreto de Melo
Antônia de Souza, Ivone
Paiva, Patrícia Maria Guedes
Napoleão, Thiago Henrique
Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome
title Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome
title_full Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome
title_fullStr Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome
title_full_unstemmed Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome
title_short Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome
title_sort antibacterial and antitumor activities of a lectin-rich preparation from microgramma vacciniifolia rhizome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866057/
https://www.ncbi.nlm.nih.gov/pubmed/35243335
http://dx.doi.org/10.1016/j.crphar.2022.100093
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