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Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome
The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate the MvRL-rich fraction from M. vacciniifolia rhizome for an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866057/ https://www.ncbi.nlm.nih.gov/pubmed/35243335 http://dx.doi.org/10.1016/j.crphar.2022.100093 |
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author | da Silva, Gabriela Cavalcante de Oliveira, Alisson Macário Costa, Wêndeo Kennedy da Silva Filho, Antônio Felix Pitta, Maira Galdino da Rocha Rêgo, Moacyr Jesus Barreto de Melo Antônia de Souza, Ivone Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique |
author_facet | da Silva, Gabriela Cavalcante de Oliveira, Alisson Macário Costa, Wêndeo Kennedy da Silva Filho, Antônio Felix Pitta, Maira Galdino da Rocha Rêgo, Moacyr Jesus Barreto de Melo Antônia de Souza, Ivone Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique |
author_sort | da Silva, Gabriela Cavalcante |
collection | PubMed |
description | The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate the MvRL-rich fraction from M. vacciniifolia rhizome for antibacterial activity in vitro and in vivo as well as antitumor effect in vivo using the Ehrlich carcinoma model in mice. The fraction showed antibacterial activity against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus with minimal inhibitory concentrations ranging from 31.2 to 125.0 μg/mL and minimal bactericidal concentrations from 62.5 to 200 μg/mL. The fraction was also effective in vivo against infection caused by these bacteria on Tenebrio molitor larvae considering the parameters evaluated. In regard to the antitumor activity, the treatments of Ehrlich carcinoma-bearing mice with the fraction at 100 and 200 mg/kg per os resulted in 62.58% and 75.43% of tumor inhibition, respectively. In conclusion, the MvRL-rich fraction showed in vivo antibacterial and antitumor activities and thus can be considered as an alternative of natural origin for the development of candidates for therapy. |
format | Online Article Text |
id | pubmed-8866057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88660572022-03-02 Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome da Silva, Gabriela Cavalcante de Oliveira, Alisson Macário Costa, Wêndeo Kennedy da Silva Filho, Antônio Felix Pitta, Maira Galdino da Rocha Rêgo, Moacyr Jesus Barreto de Melo Antônia de Souza, Ivone Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique Curr Res Pharmacol Drug Discov Research Article The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate the MvRL-rich fraction from M. vacciniifolia rhizome for antibacterial activity in vitro and in vivo as well as antitumor effect in vivo using the Ehrlich carcinoma model in mice. The fraction showed antibacterial activity against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus with minimal inhibitory concentrations ranging from 31.2 to 125.0 μg/mL and minimal bactericidal concentrations from 62.5 to 200 μg/mL. The fraction was also effective in vivo against infection caused by these bacteria on Tenebrio molitor larvae considering the parameters evaluated. In regard to the antitumor activity, the treatments of Ehrlich carcinoma-bearing mice with the fraction at 100 and 200 mg/kg per os resulted in 62.58% and 75.43% of tumor inhibition, respectively. In conclusion, the MvRL-rich fraction showed in vivo antibacterial and antitumor activities and thus can be considered as an alternative of natural origin for the development of candidates for therapy. Elsevier 2022-02-17 /pmc/articles/PMC8866057/ /pubmed/35243335 http://dx.doi.org/10.1016/j.crphar.2022.100093 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article da Silva, Gabriela Cavalcante de Oliveira, Alisson Macário Costa, Wêndeo Kennedy da Silva Filho, Antônio Felix Pitta, Maira Galdino da Rocha Rêgo, Moacyr Jesus Barreto de Melo Antônia de Souza, Ivone Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome |
title | Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome |
title_full | Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome |
title_fullStr | Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome |
title_full_unstemmed | Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome |
title_short | Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome |
title_sort | antibacterial and antitumor activities of a lectin-rich preparation from microgramma vacciniifolia rhizome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866057/ https://www.ncbi.nlm.nih.gov/pubmed/35243335 http://dx.doi.org/10.1016/j.crphar.2022.100093 |
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