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Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway
BACKGROUND: Renal fibrosis, associated with oxidative stress and nitric oxide (NO) deficiency, contributes to the development of chronic kidney disease and renal failure. As major energy source in maintaining renal physiological functions, tubular epithelial cells with decreased fatty acid oxidation...
Autores principales: | Li, Xuechen, Zhuge, Zhengbing, Carvalho, Lucas Rannier R.A., Braga, Valdir A., Lucena, Ricardo Barbosa, Li, Shuijie, Schiffer, Tomas A., Han, Huirong, Weitzberg, Eddie, Lundberg, Jon O., Carlström, Mattias |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866060/ https://www.ncbi.nlm.nih.gov/pubmed/35217293 http://dx.doi.org/10.1016/j.redox.2022.102266 |
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