Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction

OBJECTIVE: One-carbon metabolism is routinely dysregulated in nonalcoholic fatty liver disease. This includes decreased glycine N-methyltransferase (GNMT), a critical regulator of s-adenosylmethionine (SAM). Deletion of GNMT in mice increases SAM and promotes liver steatosis. Lower liver oxidative m...

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Detalles Bibliográficos
Autores principales: Rome, Ferrol I., Hughey, Curtis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866067/
https://www.ncbi.nlm.nih.gov/pubmed/35121169
http://dx.doi.org/10.1016/j.molmet.2022.101452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866067/
https://www.ncbi.nlm.nih.gov/pubmed/35121169
http://dx.doi.org/10.1016/j.molmet.2022.101452

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