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Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains

Two non-inbred mouse lines, phenotypically selected for maximal (AIRmin) and minimal (AIRmax) acute inflammatory response, show differential susceptibility/resistance to the development of several chemically-induced tumor types. An intercross pedigree of these mice was generated and treated with the...

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Autores principales: Borrego, Andrea, Jensen, José Ricardo, Cabrera, Wafa Hanna Koury, Massa, Solange, Ribeiro, Orlando Garcia, Starobinas, Nancy, De Franco, Marcelo, Eto, Silas Fernandes, Manenti, Giacomo, Dragani, Tommaso Antonio, Ibañez, Olga Martinez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866122/
https://www.ncbi.nlm.nih.gov/pubmed/34966170
http://dx.doi.org/10.1038/s41435-021-00159-z
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author Borrego, Andrea
Jensen, José Ricardo
Cabrera, Wafa Hanna Koury
Massa, Solange
Ribeiro, Orlando Garcia
Starobinas, Nancy
De Franco, Marcelo
Eto, Silas Fernandes
Manenti, Giacomo
Dragani, Tommaso Antonio
Ibañez, Olga Martinez
author_facet Borrego, Andrea
Jensen, José Ricardo
Cabrera, Wafa Hanna Koury
Massa, Solange
Ribeiro, Orlando Garcia
Starobinas, Nancy
De Franco, Marcelo
Eto, Silas Fernandes
Manenti, Giacomo
Dragani, Tommaso Antonio
Ibañez, Olga Martinez
author_sort Borrego, Andrea
collection PubMed
description Two non-inbred mouse lines, phenotypically selected for maximal (AIRmin) and minimal (AIRmax) acute inflammatory response, show differential susceptibility/resistance to the development of several chemically-induced tumor types. An intercross pedigree of these mice was generated and treated with the chemical carcinogen dimethylhydrazine, which induces lung and intestinal tumors. Genome wide high-density genotyping with the Restriction Site-Associated DNA genotyping (2B-RAD) technique was used to map genetic loci modulating individual genetic susceptibility to both lung and intestinal cancer. Our results evidence new common quantitative trait loci (QTL) for those phenotypes and provide an improved understanding of the relationship between genomic variation and individual genetic predisposition to tumorigenesis in different organs.
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spelling pubmed-88661222022-03-15 Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains Borrego, Andrea Jensen, José Ricardo Cabrera, Wafa Hanna Koury Massa, Solange Ribeiro, Orlando Garcia Starobinas, Nancy De Franco, Marcelo Eto, Silas Fernandes Manenti, Giacomo Dragani, Tommaso Antonio Ibañez, Olga Martinez Genes Immun Article Two non-inbred mouse lines, phenotypically selected for maximal (AIRmin) and minimal (AIRmax) acute inflammatory response, show differential susceptibility/resistance to the development of several chemically-induced tumor types. An intercross pedigree of these mice was generated and treated with the chemical carcinogen dimethylhydrazine, which induces lung and intestinal tumors. Genome wide high-density genotyping with the Restriction Site-Associated DNA genotyping (2B-RAD) technique was used to map genetic loci modulating individual genetic susceptibility to both lung and intestinal cancer. Our results evidence new common quantitative trait loci (QTL) for those phenotypes and provide an improved understanding of the relationship between genomic variation and individual genetic predisposition to tumorigenesis in different organs. Nature Publishing Group UK 2021-12-29 2022 /pmc/articles/PMC8866122/ /pubmed/34966170 http://dx.doi.org/10.1038/s41435-021-00159-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Borrego, Andrea
Jensen, José Ricardo
Cabrera, Wafa Hanna Koury
Massa, Solange
Ribeiro, Orlando Garcia
Starobinas, Nancy
De Franco, Marcelo
Eto, Silas Fernandes
Manenti, Giacomo
Dragani, Tommaso Antonio
Ibañez, Olga Martinez
Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains
title Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains
title_full Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains
title_fullStr Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains
title_full_unstemmed Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains
title_short Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains
title_sort mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866122/
https://www.ncbi.nlm.nih.gov/pubmed/34966170
http://dx.doi.org/10.1038/s41435-021-00159-z
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