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Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation

Itaconate is produced from the mitochondrial TCA cycle enzyme aconitase decarboxylase (encoded by immune responsive gene1; Irg1) that exerts immunomodulatory function in myeloid cells. However, the role of the Irg1/itaconate pathway in dendritic cells (DC)-mediated airway inflammation and adaptive i...

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Detalles Bibliográficos
Autores principales:	Jaiswal, Anil Kumar, Yadav, Jyoti, Makhija, Sangeet, Mazumder, Suman, Mitra, Amit Kumar, Suryawanshi, Amol, Sandey, Maninder, Mishra, Amarjit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866123/ https://www.ncbi.nlm.nih.gov/pubmed/34671116 http://dx.doi.org/10.1038/s41385-021-00462-y

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