DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

PURPOSE: In acute myeloid leukemia (AML), recurrent DNA methyltransferase 3A (DNMT3A) mutations are associated with chemoresistance and poor prognosis, especially in advanced-age patients. Gene-expression studies in DNMT3A-mutated cells identified signatures implicated in deregulated DNA damage resp...

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Detalles Bibliográficos
Autores principales: Venugopal, Kartika, Feng, Yang, Nowialis, Pawel, Xu, Huanzhou, Shabashvili, Daniil E., Berntsen, Cassandra M., Kaur, Prabhjot, Krajcik, Kathryn I., Taragjini, Christina, Zaroogian, Zachary, Casellas Román, Heidi L., Posada, Luisa M., Gunaratne, Chamara, Li, Jianping, Dupéré-Richer, Daphné, Bennett, Richard L., Pondugula, Santhi, Riva, Alberto, Cogle, Christopher R., Opavsky, Rene, Law, Brian K., Bhaduri-McIntosh, Sumita, Kubicek, Stefan, Staber, Philipp B., Licht, Jonathan D., Bird, Jonathan E., Guryanova, Olga A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866212/
https://www.ncbi.nlm.nih.gov/pubmed/34716195
http://dx.doi.org/10.1158/1078-0432.CCR-21-2863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866212/
https://www.ncbi.nlm.nih.gov/pubmed/34716195
http://dx.doi.org/10.1158/1078-0432.CCR-21-2863

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