Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma

PURPOSE: There is increasing recognition that progress in immuno-oncology could be accelerated by evaluating immune-based therapies in dogs with spontaneous cancers. Osteosarcoma (OS) is one tumor for which limited clinical benefit has been observed with the use of immune checkpoint inhibitors. We p...

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Detalles Bibliográficos
Autores principales: Regan, Daniel P., Chow, Lyndah, Das, Sunetra, Haines, Laurel, Palmer, Eric, Kurihara, Jade N., Coy, Jonathan W., Mathias, Alissa, Thamm, Douglas H., Gustafson, Daniel L., Dow, Steven W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Clinical Trials: Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866227/
https://www.ncbi.nlm.nih.gov/pubmed/34580111
http://dx.doi.org/10.1158/1078-0432.CCR-21-2105

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