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P300 and delay-discounting in obsessive–compulsive disorder

Previous research showed that dysfunctions of fronto-striatal neural networks are implicated in the pathophysiology of obsessive–compulsive disorder (OCD). Accordingly, patients with OCD showed altered performances during decision-making tasks. As P300, evoked by oddball paradigms, is suggested to b...

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Autores principales: Flasbeck, Vera, Enzi, Björn, Andreou, Christina, Juckel, Georg, Mavrogiorgou, Paraskevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866265/
https://www.ncbi.nlm.nih.gov/pubmed/34258638
http://dx.doi.org/10.1007/s00406-021-01302-7
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author Flasbeck, Vera
Enzi, Björn
Andreou, Christina
Juckel, Georg
Mavrogiorgou, Paraskevi
author_facet Flasbeck, Vera
Enzi, Björn
Andreou, Christina
Juckel, Georg
Mavrogiorgou, Paraskevi
author_sort Flasbeck, Vera
collection PubMed
description Previous research showed that dysfunctions of fronto-striatal neural networks are implicated in the pathophysiology of obsessive–compulsive disorder (OCD). Accordingly, patients with OCD showed altered performances during decision-making tasks. As P300, evoked by oddball paradigms, is suggested to be related to attentional and cognitive processes and generated in the medial temporal lobe and orbitofrontal and cingulate cortices, it is of special interest in OCD research. Therefore, this study aimed to investigate P300 in OCD and its associations with brain activity during decision-making: P300, evoked by an auditory oddball paradigm, was analysed in 19 OCD patients and 19 healthy controls regarding peak latency, amplitude and source density power in parietal cortex areas by sLORETA. Afterwards, using a fMRI paradigm, Blood–oxygen-level-dependent (BOLD) contrast imaging was conducted during a delay-discounting paradigm. We hypothesised differences between groups regarding P300 characteristics and associations with frontal activity during delay-discounting. The P300 did not differ between groups, however, the P300 latency over the P4 electrode correlated negatively with the NEO-FFI score openness to experience in patients with OCD. In healthy controls, P300 source density power correlated with activity in frontal regions when processing rewards, a finding which was absent in OCD patients. To conclude, associations of P300 with frontal brain activation during delay-discounting were found, suggesting a contribution of attentional or context updating processes. Since this association was absent in patients with OCD, the findings could be interpreted as being indeed related to dysfunctions of fronto-striatal neural networks in patients with OCD.
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spelling pubmed-88662652022-03-02 P300 and delay-discounting in obsessive–compulsive disorder Flasbeck, Vera Enzi, Björn Andreou, Christina Juckel, Georg Mavrogiorgou, Paraskevi Eur Arch Psychiatry Clin Neurosci Original Paper Previous research showed that dysfunctions of fronto-striatal neural networks are implicated in the pathophysiology of obsessive–compulsive disorder (OCD). Accordingly, patients with OCD showed altered performances during decision-making tasks. As P300, evoked by oddball paradigms, is suggested to be related to attentional and cognitive processes and generated in the medial temporal lobe and orbitofrontal and cingulate cortices, it is of special interest in OCD research. Therefore, this study aimed to investigate P300 in OCD and its associations with brain activity during decision-making: P300, evoked by an auditory oddball paradigm, was analysed in 19 OCD patients and 19 healthy controls regarding peak latency, amplitude and source density power in parietal cortex areas by sLORETA. Afterwards, using a fMRI paradigm, Blood–oxygen-level-dependent (BOLD) contrast imaging was conducted during a delay-discounting paradigm. We hypothesised differences between groups regarding P300 characteristics and associations with frontal activity during delay-discounting. The P300 did not differ between groups, however, the P300 latency over the P4 electrode correlated negatively with the NEO-FFI score openness to experience in patients with OCD. In healthy controls, P300 source density power correlated with activity in frontal regions when processing rewards, a finding which was absent in OCD patients. To conclude, associations of P300 with frontal brain activation during delay-discounting were found, suggesting a contribution of attentional or context updating processes. Since this association was absent in patients with OCD, the findings could be interpreted as being indeed related to dysfunctions of fronto-striatal neural networks in patients with OCD. Springer Berlin Heidelberg 2021-07-13 2022 /pmc/articles/PMC8866265/ /pubmed/34258638 http://dx.doi.org/10.1007/s00406-021-01302-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Flasbeck, Vera
Enzi, Björn
Andreou, Christina
Juckel, Georg
Mavrogiorgou, Paraskevi
P300 and delay-discounting in obsessive–compulsive disorder
title P300 and delay-discounting in obsessive–compulsive disorder
title_full P300 and delay-discounting in obsessive–compulsive disorder
title_fullStr P300 and delay-discounting in obsessive–compulsive disorder
title_full_unstemmed P300 and delay-discounting in obsessive–compulsive disorder
title_short P300 and delay-discounting in obsessive–compulsive disorder
title_sort p300 and delay-discounting in obsessive–compulsive disorder
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866265/
https://www.ncbi.nlm.nih.gov/pubmed/34258638
http://dx.doi.org/10.1007/s00406-021-01302-7
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